通过动态网络与多视角药物表示,提升安全用药推荐效果。
DNMDR: Dynamic Networks and Multi-view Drug Representations for Safe Medication Recommendation
- 构建患者就诊时序的加权快照序列,捕捉动态医疗事件关联。
- 在真实数据集上,PRAUC、Jaccard得分显著优于现有方法。
- 兼顾药物共现与不良相互作用,适合临床安全用药场景。
用药推荐(MR)是医疗健康领域的重要研究方向,但现有方法主要依赖序列建模和静态图结构,忽视了患者多次就诊中医疗事件的动态关联,导致节点全局结构探索不足。同时,药物间相互作用(DDIs)的缓解也是影响系统实用性的关键问题。为此,本文提出一种融合动态网络与多视角药物表示的新型推荐方法(DNMDR)。基于电子健康记录(EHR)中的离散就诊时间点,构建加权快照序列以表征动态异构网络,并联合训练所有动态网络,从而同时捕捉多样化医疗事件间的结构关联与历史健康状态的时间依赖性,实现包含语义特征与结构关系的全面患者表征。此外,结合药物分子结构内部视图(共现)与药物对交互视图(不良相互作用),生成安全的药物表示,以支持高质量的用药组合推荐。在真实数据集上的大量实验表明,所提方法在多种指标上显著超越当前最优基线模型,包括PRAUC、Jaccard相似度和药物相互作用率等。
原文摘要 · Abstract (English)
Medication Recommendation (MR) is a promising research topic which booms diverse applications in the healthcare and clinical domains. However, existing methods mainly rely on sequential modeling and static graphs for representation learning, which ignore the dynamic correlations in diverse medical events of a patient's temporal visits, leading to insufficient global structural exploration on nodes. Additionally, mitigating drug-drug interactions (DDIs) is another issue determining the utility of the MR systems. To address the challenges mentioned above, this paper proposes a novel MR method with the integration of dynamic networks and multi-view drug representations (DNMDR). Specifically, weighted snapshot sequences for dynamic heterogeneous networks are constructed based on discrete visits in temporal EHRs, and all the dynamic networks are jointly trained to gain both structural correlations in diverse medical events and temporal dependency in historical health conditions, for achieving comprehensive patient representations with both semantic features and structural relationships. Moreover, combining the drug co-occurrences and adverse drug-drug interactions (DDIs) in internal view of drug molecule structure and interactive view of drug pairs, the safe drug representations are available to obtain high-quality medication combination recommendation. Finally, extensive experiments on real world datasets are conducted for performance evaluation, and the experimental results demonstrate that the proposed DNMDR method outperforms the state-of-the-art baseline models with a large margin on various metrics such as PRAUC, Jaccard, DDI rates and so on.
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