通过空间聚类提升脑磁图癫痫尖波检测精度
Automated Detection of Epileptic Spikes and Seizures Incorporating a Novel Spatial Clustering Prior
- 按传感器位置聚类后融合时空特征
- 在桑博-CMR数据集上达94.73%的F1分数
- 适合临床神经电生理自动化分析
脑磁图(MEG)时间序列记录由超导传感器采集的多通道信号组成,每通道强度反映传感器位置处磁场随时间的变化。自动化癫痫MEG尖波检测可显著减少人工评估时间与工作量,带来明显临床价值。现有方法通常将时间窗内所有通道信号编码为神经网络输入并进行分类,但忽略了相邻传感器同时放电的现象。本文提出一种简单而有效的新范式:首先根据传感器空间位置对MEG通道进行聚类;随后设计一种新型卷积输入模块,融合空间聚类信息与信号时序变化;该模块输入至作者自研的MEEG-ResNet3D模型,学习提取关键特征并判断输入片段是否为尖波。在来自两家中心的真实世界大型MEG数据集Sanbo-CMR上,本方法取得94.73%的F1分数,优于现有最优方法1.85%。此外,在癫痫发作检测任务中也表现出色,相较于当前最优技术,在最大规模的EEG发作数据集TUSZ上实现加权F1分数提升1.4%。
原文摘要 · Abstract (English)
A Magnetoencephalography (MEG) time-series recording consists of multi-channel signals collected by superconducting sensors, with each signal's intensity reflecting magnetic field changes over time at the sensor location. Automating epileptic MEG spike detection significantly reduces manual assessment time and effort, yielding substantial clinical benefits. Existing research addresses MEG spike detection by encoding neural network inputs with signals from all channel within a time segment, followed by classification. However, these methods overlook simultaneous spiking occurred from nearby sensors. We introduce a simple yet effective paradigm that first clusters MEG channels based on their sensor's spatial position. Next, a novel convolutional input module is designed to integrate the spatial clustering and temporal changes of the signals. This module is fed into a custom MEEG-ResNet3D developed by the authors, which learns to extract relevant features and classify the input as a spike clip or not. Our method achieves an F1 score of 94.73% on a large real-world MEG dataset Sanbo-CMR collected from two centers, outperforming state-of-the-art approaches by 1.85%. Moreover, it demonstrates efficacy and stability in the Electroencephalographic (EEG) seizure detection task, yielding an improved weighted F1 score of 1.4% compared to current state-of-the-art techniques evaluated on TUSZ, whch is the largest EEG seizure dataset.
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