磁控微型机器人实现精准靶向给药，减少副作用。
Clinically Ready Magnetic Microrobots for Targeted Therapies
- 用磁导航系统+可溶胶囊设计，实现体内精准定位。
- 体外模拟血管和动物实验均成功实现导航与追踪。
- 适合需要高精度给药的癌症或血管疾病治疗。
全身给药常导致脱靶效应，限制先进疗法效果。靶向药物递送可提高病灶部位药物浓度，同时减少全身暴露。本文提出一种磁控微米机器人药物递送系统，可在生理条件下实现精确导航。该平台整合临床电磁导航系统、定制释放导管和可溶解胶囊，实现精准治疗递送。体外测试显示其在人体血管模型中具备精确导航能力；体内实验证实可在荧光透视下追踪，并在大型动物模型中成功导航。该微机器人在磁性材料浓度、对比剂载量与治疗药物容量间取得平衡，尽管组件集成复杂，仍能有效承载治疗物，为精准靶向给药提供有前景的解决方案。
原文摘要 · Abstract (English)
Systemic drug administration often causes off-target effects limiting the efficacy of advanced therapies. Targeted drug delivery approaches increase local drug concentrations at the diseased site while minimizing systemic drug exposure. We present a magnetically guided microrobotic drug delivery system capable of precise navigation under physiological conditions. This platform integrates a clinical electromagnetic navigation system, a custom-designed release catheter, and a dissolvable capsule for accurate therapeutic delivery. In vitro tests showed precise navigation in human vasculature models, and in vivo experiments confirmed tracking under fluoroscopy and successful navigation in large animal models. The microrobot balances magnetic material concentration, contrast agent loading, and therapeutic drug capacity, enabling effective hosting of therapeutics despite the integration complexity of its components, offering a promising solution for precise targeted drug delivery.
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