对比输入方式,提升OCT图像眼病分割精度。
Patch-Based and Non-Patch-Based inputs Comparison into Deep Neural Models: Application for the Segmentation of Retinal Diseases on Optical Coherence Tomography Volumes
- 用块状与整图输入对比,分析深度模型性能差异
- 块状输入使SRF分割DSC达0.88,超越人类0.71
- 适合医学图像分割研究者参考模型输入设计
全球范围内,视力丧失常由视网膜疾病引起,其中年龄相关性黄斑变性(AMD)尤为突出,目前约有1.7亿人患病,预计2040年将增至2.88亿。光学相干断层扫描(OCT)是可视化视网膜层最有效的非侵入性方法。频繁的患者随访增加了对自动分析的需求,深度学习在2D扫描图像和像素级分类中表现优异。然而,仅依赖2D数据时,定位液体病变的准确性可能下降。当前目标是让自动化技术超越人工识别能力。为理解深度学习模型的潜力,我们研究了输入尺寸的影响。基于骰子相似系数(DSC)指标,人类在分割多种视网膜疾病时得分为0.71,而深度模型已超越人类水平。进一步地,采用重叠块输入可提升模型性能,相比整图输入,块状模型在SRF液体分割中的最高DSC达到0.88。
原文摘要 · Abstract (English)
Worldwide, sight loss is commonly occurred by retinal diseases, with age-related macular degeneration (AMD) being a notable facet that affects elderly patients. Approaching 170 million persons wide-ranging have been spotted with AMD, a figure anticipated to rise to 288 million by 2040. For visualizing retinal layers, optical coherence tomography (OCT) dispenses the most compelling non-invasive method. Frequent patient visits have increased the demand for automated analysis of retinal diseases, and deep learning networks have shown promising results in both image and pixel-level 2D scan classification. However, when relying solely on 2D data, accuracy may be impaired, especially when localizing fluid volume diseases. The goal of automatic techniques is to outperform humans in manually recognizing illnesses in medical data. In order to further understand the benefit of deep learning models, we studied the effects of the input size. The dice similarity coefficient (DSC) metric showed a human performance score of 0.71 for segmenting various retinal diseases. Yet, the deep models surpassed human performance to establish a new era of advancement of segmenting the diseases on medical images. However, to further improve the performance of the models, overlapping patches enhanced the performance of the deep models compared to feeding the full image. The highest score for a patch-based model in the DSC metric was 0.88 in comparison to the score of 0.71 for the same model in non-patch-based for SRF fluid segmentation. The objective of this article is to show a fair comparison between deep learning models in relation to the input (Patch-Based vs. NonPatch-Based).
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