arXiv:2501.15973cs.LGq-bio.QM2025-01被引 4

将因果网络与概率树结合,让医疗模型不仅能预测还能模拟干预效果。

Integrating Probabilistic Trees and Causal Networks for Clinical and Epidemiological Data

  • 用因果网络结构化概率树,实现因素影响量化与干预模拟。
  • 在三个真实医疗数据集上表现媲美传统模型,且可解释性更强。
  • 适合临床决策支持,帮助医生理解可调因素对结果的影响路径。

医疗决策不仅需要精准预测,还需理解各因素如何影响患者结局。传统机器学习模型虽擅长预测高风险患者,却难以回答干预类“如果……会怎样”问题。本文提出概率因果融合(PCF)框架,整合因果贝叶斯网络(CBNs)与概率树(PTrees),利用CBNs的因果关系构建PTrees,从而同时实现因素影响量化与假设干预仿真。PCF在三个真实医疗数据集——MIMIC-IV、Framingham Heart Study和Diabetes上验证,预测性能接近传统机器学习模型,并具备额外因果推理能力。为提升可解释性,引入敏感性分析和SHAP值:前者量化因果参数对住院时长(LOS)、冠心病(CHD)及糖尿病等结局的影响,后者揭示个体特征在预测中的重要性。通过融合因果推理与预测建模,PCF弥合了临床直觉与数据驱动洞察之间的差距,能揭示可调节因素与结局间的因果路径,支持更科学的诊疗决策,在多元医疗场景中具有强适用性。

原文摘要 · Abstract (English)

Healthcare decision-making requires not only accurate predictions but also insights into how factors influence patient outcomes. While traditional Machine Learning (ML) models excel at predicting outcomes, such as identifying high risk patients, they are limited in addressing what-if questions about interventions. This study introduces the Probabilistic Causal Fusion (PCF) framework, which integrates Causal Bayesian Networks (CBNs) and Probability Trees (PTrees) to extend beyond predictions. PCF leverages causal relationships from CBNs to structure PTrees, enabling both the quantification of factor impacts and simulation of hypothetical interventions. PCF was validated on three real-world healthcare datasets i.e. MIMIC-IV, Framingham Heart Study, and Diabetes, chosen for their clinically diverse variables. It demonstrated predictive performance comparable to traditional ML models while providing additional causal reasoning capabilities. To enhance interpretability, PCF incorporates sensitivity analysis and SHapley Additive exPlanations (SHAP). Sensitivity analysis quantifies the influence of causal parameters on outcomes such as Length of Stay (LOS), Coronary Heart Disease (CHD), and Diabetes, while SHAP highlights the importance of individual features in predictive modeling. By combining causal reasoning with predictive modeling, PCF bridges the gap between clinical intuition and data-driven insights. Its ability to uncover relationships between modifiable factors and simulate hypothetical scenarios provides clinicians with a clearer understanding of causal pathways. This approach supports more informed, evidence-based decision-making, offering a robust framework for addressing complex questions in diverse healthcare settings.

因果推理医疗决策可解释性概率树

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