提出SARL-dMRI框架,同时提升dMRI的时空分辨率与微结构参数精度。
Spatial-Angular Representation Learning for High-Fidelity Continuous Super-Resolution in Diffusion MRI
- 用隐式神经表示和球谐函数建模连续空间-角度特征
- 在45倍下采样时仍保持稳定性能,显著提升微结构参数估计准确率
- 适合需要高保真dMRI重建的研究者,尤其关注神经解剖细节
扩散磁共振成像(dMRI)常因硬件限制与系统噪声导致空间和角度分辨率低下,影响精细解剖结构中微结构参数的准确估计。基于深度学习的超分辨率技术虽能提升分辨率而不增加扫描时间,但多数方法仅针对空间或角度超分,难以全面捕捉微结构特征。传统像素级损失函数也难以恢复关键细节。为此,本文提出SARL-dMRI框架,通过隐式神经表示与球谐函数建模连续空间-角度表征,同步提升空间与角度分辨率,改善微结构参数估计精度。引入数据保真模块与基于小波的频域损失,确保重建图像与原始输入一致并保留细粒度结构。大量实验表明,相比五种先进方法,本方法在45倍下采样条件下仍保持稳定性能,显著提升分辨率、参数估计准确率及泛化能力。
原文摘要 · Abstract (English)
Diffusion magnetic resonance imaging (dMRI) often suffers from low spatial and angular resolution due to inherent limitations in imaging hardware and system noise, adversely affecting the accurate estimation of microstructural parameters with fine anatomical details. Deep learning-based super-resolution techniques have shown promise in enhancing dMRI resolution without increasing acquisition time. However, most existing methods are confined to either spatial or angular super-resolution, limiting their effectiveness in capturing detailed microstructural features. Furthermore, traditional pixel-wise loss functions struggle to recover intricate image details essential for high-resolution reconstruction. To address these challenges, we propose SARL-dMRI, a novel Spatial-Angular Representation Learning framework for high-fidelity, continuous super-resolution in dMRI. SARL-dMRI explores implicit neural representations and spherical harmonics to model continuous spatial and angular representations, simultaneously enhancing both spatial and angular resolution while improving microstructural parameter estimation accuracy. To further preserve image fidelity, a data-fidelity module and wavelet-based frequency loss are introduced, ensuring the super-resolved images remain consistent with the original input and retain fine details. Extensive experiments demonstrate that, compared to five other state-of-the-art methods, our method significantly enhances dMRI data resolution, improves the accuracy of microstructural parameter estimation, and provides better generalization capabilities. It maintains stable performance even under a 45$\times$ downsampling factor.
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