通过神经信号检测耳间时间错配对听力植入者的影响,发现脑电比行为测试更敏感。
Cortical Temporal Mismatch Compensation in Bimodal Cochlear Implant Users: Selective Attention Decoding and Pupillometry Study
- 用脑电和瞳孔反应评估听觉时间错配补偿效果
- 补偿后脑电波幅值显著提升,但其他指标变化不明显
- 适合研究听觉神经机制或植入设备优化的学者
双模刺激(一侧人工耳蜗+对侧助听)虽通常提升语音理解,但受耳间时间错配影响。此前我们基于N1潜伏期差异估算该错配。本研究扩展至三种条件:临床设置、时间错配补偿、50毫秒错配。测试包括语音理解、瞳孔测量、皮层听觉诱发电位(CAEP)、选择性注意力解码及顶叶α波功率。尽管语音理解在各条件下稳定,神经指标变化更显著:补偿状态下CAEP N1P2波幅最高;相位锁定值(PLV)与注意力解码有所改善但未达显著水平;50毫秒错配时顶叶α波功率上升,提示认知资源调动;瞳孔反应与语音理解相关但灵敏度有限。结果表明神经指标比行为测试更能检测耳间时间错配。虽然补偿使CAEP N1P2波幅显著增强,其他神经指标效应有限,提示需结合时间与频谱补偿策略。
原文摘要 · Abstract (English)
Bimodal stimulation, combining cochlear implant (CI) and acoustic input from the opposite ear, typically enhances speech perception but varies due to factors like temporal mismatch. Previously, we used cortical auditory evoked potentials (CAEPs) to estimate this mismatch based on N1 latency differences. This study expands on that by assessing the impact of temporal mismatch compensation on speech perception. We tested bimodal CI users in three conditions: clinical, compensated temporal mismatch, and a 50 ms mismatch. Measures included speech understanding, pupillometry, CAEPs, selective attention decoding, and parietal alpha power. Despite stable speech understanding across conditions, neural measures showed stronger effects. CAEP N1P2 amplitudes were highest in the compensated condition. Phase-locking value (PLV) and selective attention decoding improved but lacked significance. Parietal alpha power increased under 50 ms mismatch, suggesting cognitive resource allocation. Pupillometry correlated with speech understanding but showed limited sensitivity. Findings highlight that neural metrics are more sensitive than behavioral tests for detecting interaural mismatch. While CAEP N1P2 amplitudes significantly improved with compensation, other neural measures showed limited effects, suggesting the need for combined temporal and spectral compensation strategies.
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