新模型通过神经活动模拟,更准确预测人工耳蜗用户响度感知。
A computational loudness model for electrical stimulation with cochlear implants
- 基于三维听觉系统建模,按耳蜗位置分组神经放电计算响度
- 能复现人工耳蜗用户的听阈与最适响度增长曲线
- 适用于听觉神经机制研究和听力设备算法优化
人工耳蜗(CIs)通过电刺激听觉神经纤维恢复重度感音神经性耳聋患者的听力。本研究构建了一个基于用户外周听觉系统三维表示的计算响度模型,从模拟的神经活动预测分类响度。不同于现有模型仅根据电脉冲简单推算响度,该模型将一群听觉神经纤维产生的尖峰按耳蜗位置分组,对应心理声学中的听觉滤波器生理表征,再通过时空整合获得响度指数。该指数用于定义模拟的听阈(THL)与最适响度(MCL)水平,符合实际用户中响度增长规律。通过真实用户在响度叠加实验中的表现验证了模型有效性,实验考察了刺激率、电极间距与幅度调制的影响。该模型为人工耳蜗计算框架提供了新的感知特征,缩小了仿真与人类外周神经活动之间的差距。
原文摘要 · Abstract (English)
Cochlear implants (CIs) are devices that restore the sense of hearing in people with severe sensorineural hearing loss. An electrode array inserted in the cochlea bypasses the natural transducer mechanism that transforms mechanical sound waves into neural activity by artificially stimulating the auditory nerve fibers with electrical pulses. The perception of sounds is possible because the brain extracts features from this neural activity, and loudness is among the most fundamental perceptual features. A computational model that uses a three-dimensional (3D) representation of the peripheral auditory system of CI users was developed to predict categorical loudness from the simulated peripheral neural activity. In contrast, current state-of-the-art computational loudness models predict loudness from the electrical pulses with minimal parametrization of the electrode-nerve interface. In the proposed model, the spikes produced in a population of auditory nerve fibers were grouped by cochlear places, a physiological representation of the auditory filters in psychoacoustics, to be transformed into loudness contribution. Then, a loudness index was obtained with a spatiotemporal integration over this loudness contribution. This index served to define the simulated threshold of hearing (THL) and most comfortable loudness (MCL) levels resembling the growth function in CI users. The performance of real CI users in loudness summation experiments was also used to validate the computational model. These experiments studied the effect of stimulation rate, electrode separation and amplitude modulation. The proposed model provides a new set of perceptual features that can be used in computational frameworks for CIs and narrows the gap between simulations and the human peripheral neural activity.
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