用可解释的滤波器分析步态,精准诊断帕金森病并判断严重程度
SincPD: An Explainable Method based on Sinc Filters to Diagnose Parkinson's Disease Severity by Gait Cycle Analysis
- 通过自适应sinc滤波器提取步态中的关键频率特征
- 步态段级诊断准确率达98.77%,严重程度判别达97.22%
- 滤波器从800个压缩至30个,兼顾效率与可解释性
本文提出一种基于自适应sinc滤波器的可解释深度学习分类器SincPD,用于基于步态周期分析的帕金森病(PD)诊断及严重程度评估。该方法利用穿戴在鞋底的传感器采集的垂直地面反作用力(vGRF)原始数据,通过Sinc层构建自适应带通滤波器,提取患者与健康人步态中的关键频带。训练后,采用基于质心的聚类方法对提取的滤波器按截止频率聚类,选取聚类中心作为最终滤波器,最终每传感器仅保留15个带通滤波器。通过比较各滤波器在患者与健康人中的能量差异,确定最具判别力的滤波器与传感器组合。模型在段级诊断上达到98.77%准确率,在严重程度检测中达97.22%。滤波器数量由800个缩减至30个,性能损失可忽略,显著提升效率与透明度。
原文摘要 · Abstract (English)
In this paper, an explainable deep learning-based classifier based on adaptive sinc filters for Parkinson's Disease diagnosis (PD) along with determining its severity, based on analyzing the gait cycle (SincPD) is presented. Considering the effects of PD on the gait cycle of patients, the proposed method utilizes raw data in the form of vertical Ground Reaction Force (vGRF) measured by wearable sensors placed in soles of subjects' shoes. The proposed method consists of Sinc layers that model adaptive bandpass filters to extract important frequency-bands in gait cycle of patients along with healthy subjects. Therefore, by considering these frequencies, the reasons behind the classification a person as a patient or healthy can be explained. In this method, after applying some preprocessing processes, a large model equipped with many filters is first trained. Next, to prune the extra units and reach a more explainable and parsimonious structure, the extracted filters are clusters based on their cut-off frequencies using a centroid-based clustering approach. Afterward, the medoids of the extracted clusters are considered as the final filters. Therefore, only 15 bandpass filters for each sensor are derived to classify patients and healthy subjects. Finally, the most effective filters along with the sensors are determined by comparing the energy of each filter encountering patients and healthy subjects.
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