让大模型像人脑一样智能省电，复杂句子激活更多参数。

Dense large language models(LLMs) face critical efficiency bottlenecks as they rigidly activate all parameters regardless of input complexity. While existing sparsity methods(static pruning or dynamic activation) address this partially, they either lack adaptivity to contextual or model structural demands or incur prohibitive computational overhead. Inspired by human brain's dual-process mechanisms - predictive coding (N400) for backbone sparsity and structural reanalysis (P600) for complex context - we propose CLADA, a \textit{\textbf{C}ognitive-\textbf{L}oad-\textbf{A}ware \textbf{D}ynamic \textbf{A}ctivation} framework that synergizes statistical sparsity with semantic adaptability. Our key insight is that LLM activations exhibit two complementary patterns: 1) \textit{Global statistical sparsity} driven by sequence-level prefix information, and 2) \textit{Local semantic adaptability} modulated by cognitive load metrics(e.g., surprisal and entropy). CLADA employs a hierarchical thresholding strategy: a baseline from offline error-controlled optimization ensures 40\%+ sparsity, dynamically adjusted by real-time cognitive signals. Evaluations across six mainstream LLMs and nine benchmarks demonstrate that CLADA achieves \textbf{~20\% average speedup with <2\% accuracy drop}, outperforming Griffin (5\%+ degradation) and TT (negligible speedup). Crucially, we establish the first formal connection between neurolinguistic event-related potential (ERP) components and LLM efficiency mechanisms through multi-level regression analysis ($R^2=0.17$ for sparsity-adaptation synergy). Requiring no retraining or architectural changes, CLADA offers a deployable solution for resource-aware LLM inference while advancing biologically-inspired AI design. Our code is available at \href{https://github.com/Oldify/CLADA}{CLADA}.