用生成模型模拟大脑对概念的反应,定位视觉概念相关脑区。
MindSimulator: Exploring Brain Concept Localization via Synthetic FMRI
- 基于生成模型合成脑活动数据,实现概念选择性区域的统计定位。
- 在多个已知概念脑区上验证,预测准确率表现良好。
- 为神经科学提供新假设,适合研究脑功能与概念表征的学者。
人脑皮层中概念选择性区域对特定视觉刺激有显著激活,精确定位这些区域是理解大脑功能机制的关键目标。传统实验方法依赖人工构建的视觉刺激集和对应脑活动记录,限制了概念定位的支持范围和覆盖度,且刺激常处于非自然语境,可能受主观偏好影响,导致结果有效性与泛化性存疑。为此,我们提出一种数据驱动探索方法:通过合成大规模脑活动记录,实现对多种概念选择性区域的统计定位。所提MindSimulator利用先进生成技术学习脑活动在概念导向视觉刺激下的概率分布,生成反映真实神经响应模式的模拟脑记录。基于合成数据,成功定位多个已知概念选择性区域,并与实证发现对比验证,取得良好预测准确率。该可行性为探索新型概念选择性区域开辟路径,可为未来神经科学研究提供先验假说。
原文摘要 · Abstract (English)
Concept-selective regions within the human cerebral cortex exhibit significant activation in response to specific visual stimuli associated with particular concepts. Precisely localizing these regions stands as a crucial long-term goal in neuroscience to grasp essential brain functions and mechanisms. Conventional experiment-driven approaches hinge on manually constructed visual stimulus collections and corresponding brain activity recordings, constraining the support and coverage of concept localization. Additionally, these stimuli often consist of concept objects in unnatural contexts and are potentially biased by subjective preferences, thus prompting concerns about the validity and generalizability of the identified regions. To address these limitations, we propose a data-driven exploration approach. By synthesizing extensive brain activity recordings, we statistically localize various concept-selective regions. Our proposed MindSimulator leverages advanced generative technologies to learn the probability distribution of brain activity conditioned on concept-oriented visual stimuli. This enables the creation of simulated brain recordings that reflect real neural response patterns. Using the synthetic recordings, we successfully localize several well-studied concept-selective regions and validate them against empirical findings, achieving promising prediction accuracy. The feasibility opens avenues for exploring novel concept-selective regions and provides prior hypotheses for future neuroscience research.
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