跨扫描仪与时段的脑代谢物测量高度可复现，支持罕见病研究数据合并分析。
Reproducibility Assessment of Magnetic Resonance Spectroscopy of Pregenual Anterior Cingulate Cortex across Sessions and Vendors via the Cloud Computing Platform CloudBrain-MRS
- 通过云平台在多台3T磁共振设备上重复扫描，评估代谢物浓度一致性。
- 同机内与跨机间重复性均优秀，相关系数普遍达0.9以上，P<0.01。
- 同一厂商内复现性优于跨厂商，为多中心研究提供可靠基础。
为揭示疾病机制及治疗原理，并应对不同磁共振系统厂商间采集与后处理协议不统一的问题，本研究评估了在不同扫描会话、机器型号甚至不同厂商的3T扫描仪上，前扣带皮层质子磁共振波谱（1H-MRS）获得的代谢物浓度是否具有高可复现性，对罕见病研究具有重要价值。参与者在一周内分两天各进行一次扫描（每天一次会话，每次会话包含两次1H-MRS扫描，间隔不超过5分钟，无离床活动）。通过变异系数（CV）和组内相关系数（ICC）评估会话内与会话间可靠性，通过相关系数评估跨设备复现性。结果显示，所有会话内及会话间扫描的CV值基本低于20%，多数代谢物的ICC值介于中等（0.4–0.59）至优秀（0.75–1），表明数据可靠性高；跨三台扫描仪的相关系数普遍接近1，多数在0.9左右，且均具统计学意义（P<0.01）。此外，同一厂商内部的复现性优于跨厂商之间。
原文摘要 · Abstract (English)
Given the need to elucidate the mechanisms underlying illnesses and their treatment, as well as the lack of harmonization of acquisition and post-processing protocols among different magnetic resonance system vendors, this work is to determine if metabolite concentrations obtained from different sessions, machine models and even different vendors of 3 T scanners can be highly reproducible and be pooled for diagnostic analysis, which is very valuable for the research of rare diseases. Participants underwent magnetic resonance imaging (MRI) scanning once on two separate days within one week (one session per day, each session including two proton magnetic resonance spectroscopy (1H-MRS) scans with no more than a 5-minute interval between scans (no off-bed activity)) on each machine. were analyzed for reliability of within- and between- sessions using the coefficient of variation (CV) and intraclass correlation coefficient (ICC), and for reproducibility of across the machines using correlation coefficient. As for within- and between- session, all CV values for a group of all the first or second scans of a session, or for a session were almost below 20%, and most of the ICCs for metabolites range from moderate (0.4-0.59) to excellent (0.75-1), indicating high data reliability. When it comes to the reproducibility across the three scanners, all Pearson correlation coefficients across the three machines approached 1 with most around 0.9, and majority demonstrated statistical significance (P<0.01). Additionally, the intra-vendor reproducibility was greater than the inter-vendor ones.
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