arXiv:2503.05678eess.IVcs.CV2025-03AAAI被引 6

通过历史滑窗特征聚合,高效实现病理切片中的细胞核精准检测。

Towards Effective and Efficient Context-aware Nucleus Detection in Histopathology Whole Slide Images

  • 利用历史滑窗的现成特征聚合上下文信息,无需大视野补丁。
  • 在三个基准上优于现有方法,推理速度显著提升。
  • 适合需要高精度与低延迟的病理图像分析场景。

组织病理学全切片图像(WSIs)中的细胞核检测对多种临床应用至关重要。由于WSI尺寸高达吉像素,主流方法采用滑动窗口进行检测,但独立处理每个窗口会忽略上下文信息,导致预测不准确。近期方法虽引入大视场(LFoV)补丁以提取上下文特征,但显著增加了推理延迟。本文提出一种高效且具上下文感知能力的细胞核检测方法:不使用LFoV补丁,而是聚合历史上访问过的滑窗的现成特征,大幅提升推理效率。同时,滑窗补丁具有更高放大倍率,提供更精细的组织细节,从而提升分类精度。训练时结合标注补丁及其周围未标注补丁,利用其高层组织上下文,并设计后训练策略,借助其中丰富的未标注细胞核样本增强模型上下文适应性。在三个挑战性基准上的实验结果证明该方法优越性。

原文摘要 · Abstract (English)

Nucleus detection in histopathology whole slide images (WSIs) is crucial for a broad spectrum of clinical applications. The gigapixel size of WSIs necessitates the use of sliding window methodology for nucleus detection. However, mainstream methods process each sliding window independently, which overlooks broader contextual information and easily leads to inaccurate predictions. To address this limitation, recent studies additionally crop a large Filed-of-View (LFoV) patch centered on each sliding window to extract contextual features. However, such methods substantially increase whole-slide inference latency. In this work, we propose an effective and efficient context-aware nucleus detection approach. Specifically, instead of using LFoV patches, we aggregate contextual clues from off-the-shelf features of historically visited sliding windows, which greatly enhances the inference efficiency. Moreover, compared to LFoV patches used in previous works, the sliding window patches have higher magnification and provide finer-grained tissue details, thereby enhancing the classification accuracy. To develop the proposed context-aware model, we utilize annotated patches along with their surrounding unlabeled patches for training. Beyond exploiting high-level tissue context from these surrounding regions, we design a post-training strategy that leverages abundant unlabeled nucleus samples within them to enhance the model's context adaptability. Extensive experimental results on three challenging benchmarks demonstrate the superiority of our method.

细胞核检测病理图像上下文感知高效推理

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