用距离函数生成精准形态的直肠旁淋巴结,提升医学图像合成真实度。
CAFusion: Controllable Anatomical Synthesis of Perirectal Lymph Nodes via SDF-guided Diffusion
- 基于符号距离函数解耦形状与纹理,实现可控合成
- 合成数据使分割Dice系数提升6.45%,逼近真实水平
- 适合医学影像增强与小样本学习研究者使用
病变合成方法在生成大规模合成数据集方面取得显著进展,但现有技术多聚焦于纹理合成,难以准确建模解剖复杂病灶的掩码。同时,合成过程缺乏精确控制。例如,直径1-10 mm的直肠旁淋巴结具有不规则且复杂的轮廓,现有技术难以忠实复现。为此,我们提出CAFusion,一种新型直肠旁淋巴结合成方法。通过引入符号距离函数(SDF),CAFusion生成高保真的3D解剖结构,并通过解耦形态属性(如形状、大小、位置)与纹理特征(如信号强度),实现对合成过程的灵活控制。实验表明,合成数据显著提升分割性能,Dice系数提高6.45%。在视觉图灵测试中,经验放射科医生难以区分合成与真实病灶,验证了方法在真实感与解剖准确性上的优越性。该成果为推进医学图像处理应用提供了高质量合成数据支持。
原文摘要 · Abstract (English)
Lesion synthesis methods have made significant progress in generating large-scale synthetic datasets. However, existing approaches predominantly focus on texture synthesis and often fail to accurately model masks for anatomically complex lesions. Additionally, these methods typically lack precise control over the synthesis process. For example, perirectal lymph nodes, which range in diameter from 1 mm to 10 mm, exhibit irregular and intricate contours that are challenging for current techniques to replicate faithfully. To address these limitations, we introduce CAFusion, a novel approach for synthesizing perirectal lymph nodes. By leveraging Signed Distance Functions (SDF), CAFusion generates highly realistic 3D anatomical structures. Furthermore, it offers flexible control over both anatomical and textural features by decoupling the generation of morphological attributes (such as shape, size, and position) from textural characteristics, including signal intensity. Experimental results demonstrate that our synthetic data substantially improve segmentation performance, achieving a 6.45% increase in the Dice coefficient. In the visual Turing test, experienced radiologists found it challenging to distinguish between synthetic and real lesions, highlighting the high degree of realism and anatomical accuracy achieved by our approach. These findings validate the effectiveness of our method in generating high-quality synthetic lesions for advancing medical image processing applications.
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