arXiv:2503.07110physics.med-phcs.AI2025-03被引 1

用深度学习精准预测人工心脏搏动时间点,提升血流稳定性。

A LSTM-Transformer Model for pulsation control of pVADs

  • 融合LSTM与注意力机制,构建新型预测模型。
  • 搏动时间点预测误差低至1.78毫秒,优于其他方法。
  • 适合需要高精度控制的医疗设备研发人员。

提出一种用于人工心脏(pVAD)搏动控制的新方法(AP-pVAD Model),由NPQ模型和LSTM-Transformer模型两部分组成。其中,NPQ模型建立电机转速、压力与流量间的数学关系;将Transformer的注意力模块融入LSTM网络,形成LSTM-Transformer模型,用于预测搏动时间特征点以调节电机转速。在三项液压实验和一项动物实验中验证:(1)基于NPQ模型计算的压力最大误差仅为2.15 mmHg;(2)LSTM-Transformer模型预测搏动时间特征点的最大误差为1.78ms,显著低于现有方法;(3)动物体内实验显示主动脉压力明显改善,动物存活超过27小时。结论表明,对给定pVAD,电机转速与压力呈线性关系,与流量呈二次关系;深度学习可有效预测搏动特征时间点,且在数据量有限、噪声高、超参数多样等条件下仍具鲁棒性,证明其可行性和有效性。

原文摘要 · Abstract (English)

Methods: A method of the pulsation for a pVAD is proposed (AP-pVAD Model). AP-pVAD Model consists of two parts: NPQ Model and LSTM-Transformer Model. (1)The NPQ Model determines the mathematical relationship between motor speed, pressure, and flow rate for the pVAD. (2)The Attention module of Transformer neural network is integrated into the LSTM neural network to form the new LSTM-Transformer Model to predict the pulsation time characteristic points for adjusting the motor speed of the pVAD. Results: The AP-pVAD Model is validated in three hydraulic experiments and an animal experiment. (1)The pressure provided by pVAD calculated with the NPQ Model has a maximum error of only 2.15 mmHg compared to the expected values. (2)The pulsation time characteristic points predicted by the LSTM-Transformer Model shows a maximum prediction error of 1.78ms, which is significantly lower than other methods. (3)The in-vivo test of pVAD in animal experiment has significant improvements in aortic pressure. Animals survive for over 27 hours after the initiation of pVAD operation. Conclusion: (1)For a given pVAD, motor speed has a linear relationship with pressure and a quadratic relationship with flow. (2)Deep learning can be used to predict pulsation characteristic time points, with the LSTM-Transformer Model demonstrating minimal prediction error and better robust performance under conditions of limited dataset sizes, elevated noise levels, and diverse hyperparameter combinations, demonstrating its feasibility and effectiveness.

医疗设备深度学习控制优化

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