用多上下文采样提升药物靶点预测，不依赖负样本且更准确。

Accurate prediction of drug target interactions is critical for accelerating drug discovery and elucidating complex biological mechanisms. In this work, we frame drug target prediction as a link prediction task on heterogeneous biomedical knowledge graphs (KG) that integrate drugs, proteins, diseases, pathways, and other relevant entities. Conventional KG embedding methods such as TransE and ComplEx SE are hindered by their reliance on computationally intensive negative sampling and their limited generalization to unseen drug target pairs. To address these challenges, we propose Multi Context Aware Sampling (MuCoS), a novel framework that prioritizes high-density neighbours to capture salient structural patterns and integrates these with contextual embeddings derived from BERT. By unifying structural and textual modalities and selectively sampling highly informative patterns, MuCoS circumvents the need for negative sampling, significantly reducing computational overhead while enhancing predictive accuracy for novel drug target associations and drug targets. Extensive experiments on the KEGG50k dataset demonstrate that MuCoS outperforms state-of-the-art baselines, achieving up to a 13\% improvement in mean reciprocal rank (MRR) in predicting any relation in the dataset and a 6\% improvement in dedicated drug target relation prediction.