用傅里叶时空注意力提升脑连接估计,抗噪更强、精度更高。
Brain Effective Connectivity Estimation via Fourier Spatiotemporal Attention
- 联合傅里叶变换与时空注意力,同步捕捉脑区间动态与时间依赖。
- 在模拟与真实静息态fMRI数据上,优于现有最先进方法。
- 适合神经科学、脑网络建模及医学影像分析研究者使用。
从功能磁共振成像(fMRI)数据中估计脑有效连接(EC)有助于理解人类行为与认知的神经机制,并为疾病诊断提供基础。然而,现有时空注意力模块通常将时间与空间注意力分开处理,或串行或并行提取特征,忽略了真实fMRI数据中固有的时空相关性。此外,fMRI数据中的噪声也限制了现有方法的性能。本文提出一种基于傅里叶时空注意力(FSTA-EC)的新方法,通过结合傅里叶注意力与时空注意力,同时从高噪声fMRI数据中捕获跨序列(空间)动态与序列内(时间)依赖关系。具体而言,傅里叶注意力将高噪声fMRI数据转换至频域,进行去噪后映射回物理域;而时空注意力则协同学习时空动态。通过理论证明,将可学习滤波器嵌入快速傅里叶变换(FFT)与逆快速傅里叶变换(IFFT)过程,数学上等价于循环卷积。在模拟与真实静息态fMRI数据集上的实验结果表明,所提方法显著优于当前最优方法。
原文摘要 · Abstract (English)
Estimating brain effective connectivity (EC) from functional magnetic resonance imaging (fMRI) data can aid in comprehending the neural mechanisms underlying human behavior and cognition, providing a foundation for disease diagnosis. However, current spatiotemporal attention modules handle temporal and spatial attention separately, extracting temporal and spatial features either sequentially or in parallel. These approaches overlook the inherent spatiotemporal correlations present in real world fMRI data. Additionally, the presence of noise in fMRI data further limits the performance of existing methods. In this paper, we propose a novel brain effective connectivity estimation method based on Fourier spatiotemporal attention (FSTA-EC), which combines Fourier attention and spatiotemporal attention to simultaneously capture inter-series (spatial) dynamics and intra-series (temporal) dependencies from high-noise fMRI data. Specifically, Fourier attention is designed to convert the high-noise fMRI data to frequency domain, and map the denoised fMRI data back to physical domain, and spatiotemporal attention is crafted to simultaneously learn spatiotemporal dynamics. Furthermore, through a series of proofs, we demonstrate that incorporating learnable filter into fast Fourier transform and inverse fast Fourier transform processes is mathematically equivalent to performing cyclic convolution. The experimental results on simulated and real-resting-state fMRI datasets demonstrate that the proposed method exhibits superior performance when compared to state-of-the-art methods.
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