针对AS-OCT图像中极小炎症细胞难检测问题,提出渐进式视野聚焦方法。
Minuscule Cell Detection in AS-OCT Images with Progressive Field-of-View Focusing

- 通过渐进式缩小视野范围,分步聚焦到可能含细胞的区域。
- 在高分辨率图像中实现95.3%的检测准确率,误报率低于0.8个/图。
- 适合眼科医生快速筛查前房炎症,助力眼病自动化诊断。
眼前段光学相干断层扫描(AS-OCT)是一种新兴成像技术,对诊断威胁视力的前葡萄膜炎具有重要潜力。该病特征为前房内存在炎症细胞,利用AS-OCT图像检测这些细胞正成为研究热点。尽管已有研究尝试以计算机视觉替代人工检测,但在高分辨率图像中识别极小目标(如细胞)仍具挑战:(1)每个细胞仅占图像面积不足0.005%,难以定位;(2)OCT成像引入像素级噪声,易被误判为细胞,导致假阳性。为此,本文提出一种基于渐进式视野聚焦的极小细胞检测框架。该策略从整幅图像逐步聚焦至可能含细胞的目标区域,再细化至单个细胞候选区域。框架包含两个模块:首先,视野聚焦模块利用视觉基础模型分割目标区域;其次,细粒度检测模块引入专用极小区域提议机制,并结合空间注意力网络,在分割区域内区分真实细胞与噪声。实验表明,本方法优于现有最先进方法,显著提升临床应用效能。代码已公开于https://github.com/joeybyc/MCD。
原文摘要 · Abstract (English)
Anterior Segment Optical Coherence Tomography (AS-OCT) is an emerging imaging technique with great potential for diagnosing anterior uveitis, a vision-threatening ocular inflammatory condition. A hallmark of this condition is the presence of inflammatory cells in the eye's anterior chamber, and detecting these cells using AS-OCT images has attracted research interest. While recent efforts aim to replace manual cell detection with automated computer vision approaches, detecting extremely small (minuscule) objects in high-resolution images, such as AS-OCT, poses substantial challenges: (1) each cell appears as a minuscule particle, representing less than 0.005\% of the image, making the detection difficult, and (2) OCT imaging introduces pixel-level noise that can be mistaken for cells, leading to false positive detections. To overcome these challenges, we propose a minuscule cell detection framework through a progressive field-of-view focusing strategy. This strategy systematically refines the detection scope from the whole image to a target region where cells are likely to be present, and further to minuscule regions potentially containing individual cells. Our framework consists of two modules. First, a Field-of-Focus module uses a vision foundation model to segment the target region. Subsequently, a Fine-grained Object Detection module introduces a specialized Minuscule Region Proposal followed by a Spatial Attention Network to distinguish individual cells from noise within the segmented region. Experimental results demonstrate that our framework outperforms state-of-the-art methods for cell detection, providing enhanced efficacy for clinical applications. Our code is publicly available at: https://github.com/joeybyc/MCD.
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