arXiv:2503.15718cs.CL2025-03被引 1

让患者用自己话描述病情,自动判断能否参加临床试验。

Am I eligible? Natural Language Inference for Clinical Trial Patient Recruitment: the Patient's Point of View

  • 用患者口语描述病史,匹配临床试验条件
  • 最佳模型在患者语言下仍达71.8的F1分数
  • 适合想直接面向患者的临床试验招募系统

临床试验患者招募常耗时费力。当前通常由医生向患者推荐,但直接面向患者在线招募可能更高效。本研究关注患者主动查询自身是否符合某项临床试验的情况,使用其自述的医学表述进行匹配。为此,我们构建了新的数据集NLI4PR,基于TREC 2022临床试验赛道数据,将专业医疗描述人工改写为患者常用语言,并保留原始入组/排除结果。我们测试多个开源大模型在此任务上的表现,发现使用患者语言时模型F1得分在56.5至71.8之间,略低于使用医学语言时的64.7至73.1,但性能下降微小。结果表明,以患者语言为起点的匹配机制具备可行性。数据与代码已公开于GitHub和HuggingFace。

原文摘要 · Abstract (English)

Recruiting patients to participate in clinical trials can be challenging and time-consuming. Usually, participation in a clinical trial is initiated by a healthcare professional and proposed to the patient. Promoting clinical trials directly to patients via online recruitment might help to reach them more efficiently. In this study, we address the case where a patient is initiating their own recruitment process and wants to determine whether they are eligible for a given clinical trial, using their own language to describe their medical profile. To study whether this creates difficulties in the patient trial matching process, we design a new dataset and task, Natural Language Inference for Patient Recruitment (NLI4PR), in which patient language profiles must be matched to clinical trials. We create it by adapting the TREC 2022 Clinical Trial Track dataset, which provides patients' medical profiles, and rephrasing them manually using patient language. We also use the associated clinical trial reports where the patients are either eligible or excluded. We prompt several open-source Large Language Models on our task and achieve from 56.5 to 71.8 of F1 score using patient language, against 64.7 to 73.1 for the same task using medical language. When using patient language, we observe only a small loss in performance for the best model, suggesting that having the patient as a starting point could be adopted to help recruit patients for clinical trials. The corpus and code bases are all freely available on our Github and HuggingFace repositories.

临床试验自然语言推理患者招募大模型应用

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