arXiv:2503.16452cs.HCcs.AI2025-03被引 2

用运动扰动分析婴儿动作特征,找早期脑瘫预测的生物标志物。

Towards Biomarker Discovery for Early Cerebral Palsy Detection: Evaluating Explanations Through Kinematic Perturbations

  • 通过速度和角度扰动测试关键点对模型预测的影响。
  • 手臂、髋部和腿部的速度特征主导脑瘫风险判断。
  • 两种解释方法部分一致,适合临床验证的生物标志物发现。

脑瘫(CP)是儿童中常见的运动障碍,早期检测可显著改善治疗效果。尽管基于骨骼的图卷积网络(GCN)模型在从婴儿视频中自动预测脑瘫风险方面表现出潜力,但其“黑箱”特性引发了临床可解释性的担忧。为此,我们提出一种针对婴儿运动特征的扰动框架,用于比较两种可解释AI方法:类激活映射(CAM)与梯度加权类激活映射(Grad-CAM)。首先,根据XAI归因分数识别低风险与高风险婴儿视频片段中的显著与非显著身体关键点。随后,对这些关键点分别进行速度与角度扰动,单独及联合施加,评估GCN模型风险预测的变化。结果表明,上肢、髋部和下肢的速度特征对脑瘫风险预测具有主导作用,而角度扰动影响较小。此外,CAM与Grad-CAM在高低风险组中展现出部分一致性。研究证明了基于XAI的运动分析可用于早期脑瘫预测,并为潜在的运动生物标志物发现提供了依据,需进一步临床验证。

原文摘要 · Abstract (English)

Cerebral Palsy (CP) is a prevalent motor disability in children, for which early detection can significantly improve treatment outcomes. While skeleton-based Graph Convolutional Network (GCN) models have shown promise in automatically predicting CP risk from infant videos, their "black-box" nature raises concerns about clinical explainability. To address this, we introduce a perturbation framework tailored for infant movement features and use it to compare two explainable AI (XAI) methods: Class Activation Mapping (CAM) and Gradient-weighted Class Activation Mapping (Grad-CAM). First, we identify significant and non-significant body keypoints in very low- and very high-risk infant video snippets based on the XAI attribution scores. We then conduct targeted velocity and angular perturbations, both individually and in combination, on these keypoints to assess how the GCN model's risk predictions change. Our results indicate that velocity-driven features of the arms, hips, and legs have a dominant influence on CP risk predictions, while angular perturbations have a more modest impact. Furthermore, CAM and Grad-CAM show partial convergence in their explanations for both low- and high-risk CP groups. Our findings demonstrate the use of XAI-driven movement analysis for early CP prediction and offer insights into potential movement-based biomarker discovery that warrant further clinical validation.

脑瘫检测可解释AI运动分析生物标志物

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