arXiv:2503.16533cs.CLcs.AI2025-03被引 3

用大模型把病历和对话转成患者旅程知识图谱

From Patient Consultations to Graphs: Leveraging LLMs for Patient Journey Knowledge Graph Construction

  • 用大模型解析临床记录和医患对话,构建结构化知识图谱
  • 四种模型均达结构合规,但医学实体识别与效率有差异
  • 适合医疗数据整合、精准医疗研究者参考

向以患者为中心的医疗转型需要全面理解患者旅程,即贯穿整个医疗体系的所有健康经历与互动。现有医疗数据系统常呈碎片化,缺乏对患者轨迹的整体呈现,制约了协同照护与个性化干预。患者旅程知识图谱(PJKGs)通过将多样化的患者信息整合为统一、结构化的表示,为解决数据碎片化问题提供了新思路。本文提出一种基于大语言模型(LLMs)构建PJKGs的方法,用于处理正式临床文档和非结构化医患对话。这些图谱刻画了临床事件、诊断、治疗与结果之间的时序与因果关系,支持高级时序推理和个性化照护洞察。研究评估了Claude 3.5、Mistral、Llama 3.1和ChatGPT4o四种模型在生成准确且计算高效的知识图谱方面的能力。结果显示,所有模型均实现完美结构合规,但在医学实体处理能力和计算效率上存在差异。论文最后指出关键挑战与未来方向。本研究推动了以患者为中心的医疗发展,构建了可行动的综合性知识图谱,支持更优的照护协调与预后预测。

原文摘要 · Abstract (English)

The transition towards patient-centric healthcare necessitates a comprehensive understanding of patient journeys, which encompass all healthcare experiences and interactions across the care spectrum. Existing healthcare data systems are often fragmented and lack a holistic representation of patient trajectories, creating challenges for coordinated care and personalized interventions. Patient Journey Knowledge Graphs (PJKGs) represent a novel approach to addressing the challenge of fragmented healthcare data by integrating diverse patient information into a unified, structured representation. This paper presents a methodology for constructing PJKGs using Large Language Models (LLMs) to process and structure both formal clinical documentation and unstructured patient-provider conversations. These graphs encapsulate temporal and causal relationships among clinical encounters, diagnoses, treatments, and outcomes, enabling advanced temporal reasoning and personalized care insights. The research evaluates four different LLMs, such as Claude 3.5, Mistral, Llama 3.1, and Chatgpt4o, in their ability to generate accurate and computationally efficient knowledge graphs. Results demonstrate that while all models achieved perfect structural compliance, they exhibited variations in medical entity processing and computational efficiency. The paper concludes by identifying key challenges and future research directions. This work contributes to advancing patient-centric healthcare through the development of comprehensive, actionable knowledge graphs that support improved care coordination and outcome prediction.

知识图谱大模型医疗数据

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