用生成模型合成真实感脑电数据,帮医生训练定位电极。
MerGen: Micro-electrode recording synthesis using a generative data-driven approach
- 用生成神经网络从零合成脑电数据,模拟真实信号
- 专家听不出生成信号与真实信号的差别,效果接近真人水平
- 可定制特定手术场景,适合临床培训与手术辅助
电生理数据分析对深部脑刺激等神经外科手术至关重要,术中通过听觉判断电极位置以优化疗效,但需专家经验且培训成本高。本文提出名为MerGen的生成式神经网络,能从头合成逼真的微电极记录信号,作为临床培训的仿真工具。实验表明,专家无法区分生成信号与真实信号;且可通过条件控制生成特定手术场景信号,其一致性优于专家间的个体差异与跨人差异。该方法还可用于增强自动信号分类的数据,支持术中决策。
原文摘要 · Abstract (English)
The analysis of electrophysiological data is crucial for certain surgical procedures such as deep brain stimulation, which has been adopted for the treatment of a variety of neurological disorders. During the procedure, auditory analysis of these signals helps the clinical team to infer the neuroanatomical location of the stimulation electrode and thus optimize clinical outcomes. This task is complex, and requires an expert who in turn requires significant training. In this paper, we propose a generative neural network, called MerGen, capable of simulating de novo electrophysiological recordings, with a view to providing a realistic learning tool for clinicians trainees for identifying these signals. We demonstrate that the generated signals are perceptually indistinguishable from real signals by experts in the field, and that it is even possible to condition the generation efficiently to provide a didactic simulator adapted to a particular surgical scenario. The efficacy of this conditioning is demonstrated, comparing it to intra-observer and inter-observer variability amongst experts. We also demonstrate the use of this network for data augmentation for automatic signal classification which can play a role in decision-making support in the operating theatre.
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