通过信噪比信息训练，提升MRI去噪模型在不同场景下的性能与泛化能力。

To develop and evaluate a new deep learning MR denoising method that leverages quantitative noise distribution information from the reconstruction process to improve denoising performance and generalization. This retrospective study trained 14 different transformer and convolutional models with two backbone architectures on a large dataset of 2,885,236 images from 96,605 cardiac retro-gated cine complex series acquired at 3T. The proposed training scheme, termed SNRAware, leverages knowledge of the MRI reconstruction process to improve denoising performance by simulating large, high quality, and diverse synthetic datasets, and providing quantitative information about the noise distribution to the model. In-distribution testing was performed on a hold-out dataset of 3000 samples with performance measured using PSNR and SSIM, with ablation comparison without the noise augmentation. Out-of-distribution tests were conducted on cardiac real-time cine, first-pass cardiac perfusion, and neuro and spine MRI, all acquired at 1.5T, to test model generalization across imaging sequences, dynamically changing contrast, different anatomies, and field strengths. The best model found in the in-distribution test generalized well to out-of-distribution samples, delivering 6.5x and 2.9x CNR improvement for real-time cine and perfusion imaging, respectively. Further, a model trained with 100% cardiac cine data generalized well to a T1 MPRAGE neuro 3D scan and T2 TSE spine MRI.