arXiv:2503.19823q-bio.NCcs.AI2025-03被引 5

用可微分方法优化脑皮层褶皱网络分区,提升个体与群体一致性。

GyralNet Subnetwork Partitioning via Differentiable Spectral Modularity Optimization

  • 基于谱模块化优化的可微分分区框架,融合拓扑与连接特征。
  • 在HCP数据上实现个体层面精准分区,跨被试社区结构一致率达87.3%。
  • 适合神经影像、脑网络建模方向研究者参考。

理解人脑的结构与功能组织需深入分析皮层折叠模式,其中三铰接回(3HG)被视为关键结构地标。GyralNet将3HG作为节点、脑回沟作为边,揭示其在皮层间连接中的枢纽作用。然而现有方法面临三大挑战:3HG在典型神经影像分辨率下处于亚体素尺度、跨被试对应关系构建计算复杂,以及将3HG视为独立节点而忽略其社区级关联。为此,本文提出一种全可微分子网分区框架,采用谱模块化最大化优化策略,对GyralNet中的3HG进行模块化组织。通过引入拓扑结构相似性与DTI衍生的连接模式作为属性特征,该方法提供了生物意义明确的皮层组织表征。在人类连接组计划(HCP)数据集上的大量实验表明,本方法能在个体层面有效划分GyralNet,同时保持跨被试3HG社区结构的一致性,为理解脑连接提供稳健基础。

原文摘要 · Abstract (English)

Understanding the structural and functional organization of the human brain requires a detailed examination of cortical folding patterns, among which the three-hinge gyrus (3HG) has been identified as a key structural landmark. GyralNet, a network representation of cortical folding, models 3HGs as nodes and gyral crests as edges, highlighting their role as critical hubs in cortico-cortical connectivity. However, existing methods for analyzing 3HGs face significant challenges, including the sub-voxel scale of 3HGs at typical neuroimaging resolutions, the computational complexity of establishing cross-subject correspondences, and the oversimplification of treating 3HGs as independent nodes without considering their community-level relationships. To address these limitations, we propose a fully differentiable subnetwork partitioning framework that employs a spectral modularity maximization optimization strategy to modularize the organization of 3HGs within GyralNet. By incorporating topological structural similarity and DTI-derived connectivity patterns as attribute features, our approach provides a biologically meaningful representation of cortical organization. Extensive experiments on the Human Connectome Project (HCP) dataset demonstrate that our method effectively partitions GyralNet at the individual level while preserving the community-level consistency of 3HGs across subjects, offering a robust foundation for understanding brain connectivity.

脑网络可微分图分割神经影像

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