用人类脑影像知识迁移,提升灵长类脑部组织分割精度。
Nonhuman Primate Brain Tissue Segmentation Using a Transfer Learning Approach
- 通过迁移学习将人类脑影像知识迁移到灵长类脑部,增强小样本下的分割能力。
- 对尾状核、丘脑等微小结构分割效果显著,DSC超0.88,IoU超0.8,HD95低于7。
- 适合从事进化神经科学与人类神经疾病动物模型研究的团队使用。
非人灵长类(NHP)因其与人类的近缘关系,在理解人类脑功能和神经疾病方面具有关键作用。然而,由于缺乏标注的NHP脑部MRI数据集、脑部体积小、成像分辨率有限以及人与灵长类脑部解剖差异,其脑组织分割面临挑战。为此,我们提出一种新方法:结合STU-Net与迁移学习,利用人类脑部MRI数据的知识提升有限训练数据下灵长类脑部影像的分割精度。该方法有效勾勒复杂组织边界,捕捉灵长类特有的精细解剖结构。尤其在分辨小体积亚皮层结构(如尾状核、丘脑)方面表现突出,在低空间分辨率与弱组织对比条件下仍能实现超过0.88的骰子相似系数(DSC)、超过0.8的交并比(IoU),以及低于7的95%豪斯多夫距离(HD95)。本研究为灵长类多类脑组织分割提供了可靠方案,有望加速进化神经科学及与人类健康相关的神经疾病临床前研究。
原文摘要 · Abstract (English)
Non-human primates (NHPs) serve as critical models for understanding human brain function and neurological disorders due to their close evolutionary relationship with humans. Accurate brain tissue segmentation in NHPs is critical for understanding neurological disorders, but challenging due to the scarcity of annotated NHP brain MRI datasets, the small size of the NHP brain, the limited resolution of available imaging data and the anatomical differences between human and NHP brains. To address these challenges, we propose a novel approach utilizing STU-Net with transfer learning to leverage knowledge transferred from human brain MRI data to enhance segmentation accuracy in the NHP brain MRI, particularly when training data is limited. The combination of STU-Net and transfer learning effectively delineates complex tissue boundaries and captures fine anatomical details specific to NHP brains. Notably, our method demonstrated improvement in segmenting small subcortical structures such as putamen and thalamus that are challenging to resolve with limited spatial resolution and tissue contrast, and achieved DSC of over 0.88, IoU over 0.8 and HD95 under 7. This study introduces a robust method for multi-class brain tissue segmentation in NHPs, potentially accelerating research in evolutionary neuroscience and preclinical studies of neurological disorders relevant to human health.
Thank you to arXiv for use of its open access interoperability. PaperDance 不是 arXiv 官方产品;中文卡片由大模型生成,请以原文为准。