arXiv:2503.23653stat.MLcs.LG2025-03被引 4

用几何方法高效分析脑网络相关矩阵,提升预测与推断能力

Scalable Geometric Learning with Correlation-Based Functional Brain Networks

  • 通过微分同胚变换将相关矩阵映射到欧氏空间,保留流形特性
  • 计算速度更快、精度更高,适用于大规模脑网络分析
  • 适合神经影像研究者用于行为预测、个体识别和脑电假设检验

相关矩阵是神经影像中功能脑网络的核心表征。传统分析常在欧氏空间中独立处理成对交互,忽视相关矩阵的内在几何结构。尽管早期工作尝试采用相关流形的商几何,但受限于计算效率低和数值不稳定性,尤其在高维情况下表现不佳。本文提出一种新型几何框架,利用微分同胚变换将相关矩阵嵌入欧氏空间,同时保持关键流形性质,支持大规模分析。该方法可与回归、降维、聚类等经典学习算法集成,并自然扩展至群体水平的脑网络推断。模拟研究表明,相比传统流形方法,本方法在计算速度和准确性上均有提升。真实神经影像应用显示,该框架能有效增强行为评分预测、静息态fMRI中的个体指纹识别以及脑电数据的假设检验能力。配套开源MATLAB工具箱已发布,便于推广和推动相关几何方法在功能脑网络研究中的应用。

原文摘要 · Abstract (English)

The correlation matrix is a central representation of functional brain networks in neuroimaging. Traditional analyses often treat pairwise interactions independently in a Euclidean setting, overlooking the intrinsic geometry of correlation matrices. While earlier attempts have embraced the quotient geometry of the correlation manifold, they remain limited by computational inefficiency and numerical instability, particularly in high-dimensional contexts. This paper presents a novel geometric framework that employs diffeomorphic transformations to embed correlation matrices into a Euclidean space, preserving salient manifold properties and enabling large-scale analyses. The proposed method integrates with established learning algorithms - regression, dimensionality reduction, and clustering - and extends naturally to population-level inference of brain networks. Simulation studies demonstrate both improved computational speed and enhanced accuracy compared to conventional manifold-based approaches. Moreover, applications in real neuroimaging scenarios illustrate the framework's utility, enhancing behavior score prediction, subject fingerprinting in resting-state fMRI, and hypothesis testing in electroencephalogram data. An open-source MATLAB toolbox is provided to facilitate broader adoption and advance the application of correlation geometry in functional brain network research.

脑网络几何学习相关矩阵神经影像

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