用7T数据指导3T fMRI重建,提升脑成像分辨率与信噪比。
Schrödinger Diffusion Driven Signal Recovery in 3T BOLD fMRI Using Unmatched 7T Observations
- 通过共享低维空间映射不同个体的3T与7T数据
- 用无监督薛定谔桥方法生成高信噪比、高分辨率3T图像
- 适合需要高质量脑成像但仅能使用3T设备的研究者
超高场(7特斯拉)BOLD fMRI在时空分辨率和信噪比方面表现优异,是研究视觉信息处理的强大工具。然而由于7T扫描仪普及度低,多数神经影像研究仍依赖3T系统,其固有分辨率与信噪比较低。为缓解此问题,本文提出一种新计算方法,旨在提升3T BOLD fMRI质量。具体而言,将来自不同个体、不同实验设置的3T与7T数据投影至共享低维表示空间,并在该空间中采用轻量级无监督薛定谔桥框架,推断出高信噪比、高分辨率的3T数据版本,无需配对标注。该方法在多个fMRI视网膜拓扑数据集上进行评估,包括合成数据,结果表明增强后的3T输出显著提升了群体感受野(pRF)模型的可靠性与拟合度。研究证实,可通过计算手段从标准3T采集中逼近7T级成像质量。
原文摘要 · Abstract (English)
Ultra-high-field (7 Tesla) BOLD fMRI offers exceptional detail in both spatial and temporal domains, along with robust signal-to-noise characteristics, making it a powerful modality for studying visual information processing in the brain. However, due to the limited accessibility of 7T scanners, the majority of neuroimaging studies are still conducted using 3T systems, which inherently suffer from reduced fidelity in both resolution and SNR. To mitigate this limitation, we introduce a new computational approach designed to enhance the quality of 3T BOLD fMRI acquisitions. Specifically, we project both 3T and 7T datasets, sourced from different individuals and experimental setups, into a shared low-dimensional representation space. Within this space, we employ a lightweight, unsupervised Schrödinger Bridge framework to infer a high-SNR, high-resolution counterpart of the 3T data, without relying on paired supervision. This methodology is evaluated across multiple fMRI retinotopy datasets, including synthetically generated samples, and demonstrates a marked improvement in the reliability and fit of population receptive field (pRF) models applied to the enhanced 3T outputs. Our findings suggest that it is feasible to computationally approximate 7T-level quality from standard 3T acquisitions.
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