用新方法发现孩子大脑在任务和静息态间更相似,反映注意力更稳定。
BOLDSimNet: Examining Brain Network Similarity between Task and Resting-State fMRI
- 基于多变量转移熵,按功能分组脑区提升网络对齐精度
- 40名健康人数据表明儿童状态间相似性更高,青少年差异更大
- 适合研究发育期注意力变化与脑网络可塑性的人群
传统任务态与静息态功能磁共振成像的因果连接方法因噪声敏感及无法建模多变量依赖关系,难以准确捕捉定向信息流,阻碍了不同认知状态下脑网络的比较。为此,我们提出BOLDSimNet框架,利用多变量转移熵(MTE)测量不同认知状态间的因果连接与网络相似性。该方法按功能相似性聚类感兴趣区域(ROIs),而非基于空间邻近性,提升网络对齐准确性。在40名健康对照者的fMRI数据上应用发现:儿童在任务态与静息态间具有更高的相似性得分,表明其注意力转换变异较小;而青少年在背侧注意网络(DAN)和默认模式网络(DMN)中表现出更大差异,反映更强的网络可塑性。结果揭示了脑网络重配置的发育差异,验证了BOLDSimNet量化网络相似性和识别注意力波动的能力。
原文摘要 · Abstract (English)
Traditional causal connectivity methods in task-based and resting-state functional magnetic resonance imaging (fMRI) face challenges in accurately capturing directed information flow due to their sensitivity to noise and inability to model multivariate dependencies. These limitations hinder the effective comparison of brain networks between cognitive states, making it difficult to analyze network reconfiguration during task and resting states. To address these issues, we propose BOLDSimNet, a novel framework utilizing Multivariate Transfer Entropy (MTE) to measure causal connectivity and network similarity across different cognitive states. Our method groups functionally similar regions of interest (ROIs) rather than spatially adjacent nodes, improving accuracy in network alignment. We applied BOLDSimNet to fMRI data from 40 healthy controls and found that children exhibited higher similarity scores between task and resting states compared to adolescents, indicating reduced variability in attention shifts. In contrast, adolescents showed more differences between task and resting states in the Dorsal Attention Network (DAN) and the Default Mode Network (DMN), reflecting enhanced network adaptability. These findings emphasize developmental variations in the reconfiguration of the causal brain network, showcasing BOLDSimNet's ability to quantify network similarity and identify attentional fluctuations between different cognitive states.
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