arXiv:2504.01547cs.CV2025-04被引 4

用扩散模型生成更准的伪标签,少标注也能高精度分割生物医学图像。

Semi-Supervised Biomedical Image Segmentation via Diffusion Models and Teacher-Student Co-Training

  • 用扩散模型通过去噪反推结构信息,生成高质量伪标签。
  • 在仅1%标注数据下,分割性能超越现有方法,3D心脏分割达90.2% Dice。
  • 适合标注稀缺的医疗图像场景,尤其适合研究者和临床应用。

监督深度学习在生物医学图像分割中表现优异,但依赖昂贵的像素级标注,推动了半监督方法的发展。本文提出一种基于扩散模型的教师-学生框架,利用分割预测条件化图像去噪,促进生成更具信息量的伪标签。教师首先通过无监督重建任务预训练,使用扩散式污染、时间步条件与去噪机制;从被污染的空掩码出发,模型预测中间分割结果以条件化图像去噪,促使预测掩码捕捉对恢复原始图像有用的结构信息。随后,教师与学生共同训练:在标注样本上进行监督分割,在未标注数据上实现交叉伪监督。我们进一步引入多轮扩展机制,在共训练中让教师生成多个随机图像重构及其对应分割预测,提供额外重构与对齐信号以优化伪标签。我们在三个公开2D生物医学分割数据集和一个3D左心房分割基准上评估该框架。在多种标注比例下,本方法表现优于或媲美当前最优半监督方法,尤其在严重标注稀缺条件下提升最显著。

原文摘要 · Abstract (English)

Supervised deep learning achieves strong performance in biomedical image segmentation but relies on costly pixel-wise annotations, motivating semi-supervised approaches that exploit unlabeled data. We introduce a diffusion-based teacher--student framework in which segmentation predictions are used to condition image denoising, encouraging the production of more informative pseudo-labels. The teacher is first pretrained through an unsupervised reconstruction task using diffusion-style corruption, timestep conditioning, and denoising. Starting from a corrupted empty mask, the model predicts an intermediate segmentation that conditions image denoising, encouraging the predicted mask to capture structural information useful for recovering the original image. The resulting teacher is then co-trained with a student using supervised segmentation on labeled samples and cross pseudo-supervision on unlabeled data. We further introduce a multi-round extension during co-training, in which the teacher generates multiple stochastic image reconstructions and corresponding segmentation predictions, providing additional reconstruction and alignment signals to improve its pseudo-labels. We evaluate the proposed framework on three public 2D biomedical segmentation datasets and a 3D left atrial segmentation benchmark. Across several labeling regimes, our method achieves competitive or superior performance compared with state-of-the-art semi-supervised approaches, with the largest gains observed under severe label scarcity.

扩散模型半监督图像分割生物医学

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