用优化算法提升肾病检测准确率，模型达98.75%准确率且可解释。

Chronic Kidney Disease (CKD) is a major global health issue which is affecting million people around the world and with increasing rate of mortality. Mitigation of progression of CKD and better patient outcomes requires early detection. Nevertheless, limitations lie in traditional diagnostic methods, especially in resource constrained settings. This study proposes an advanced machine learning approach to enhance CKD detection by evaluating four models: Random Forest (RF), Multi-Layer Perceptron (MLP), Logistic Regression (LR), and a fine-tuned CatBoost algorithm. Specifically, among these, the fine-tuned CatBoost model demonstrated the best overall performance having an accuracy of 98.75%, an AUC of 0.9993 and a Kappa score of 97.35% of the studies. The proposed CatBoost model has used a nature inspired algorithm such as Simulated Annealing to select the most important features, Cuckoo Search to adjust outliers and grid search to fine tune its settings in such a way to achieve improved prediction accuracy. Features significance is explained by SHAP-a well-known XAI technique-for gaining transparency in the decision-making process of proposed model and bring up trust in diagnostic systems. Using SHAP, the significant clinical features were identified as specific gravity, serum creatinine, albumin, hemoglobin, and diabetes mellitus. The potential of advanced machine learning techniques in CKD detection is shown in this research, particularly for low income and middle-income healthcare settings where prompt and correct diagnoses are vital. This study seeks to provide a highly accurate, interpretable, and efficient diagnostic tool to add to efforts for early intervention and improved healthcare outcomes for all CKD patients.