针对医学图像分割中的类别不平衡问题，提出自适应损失函数CALF提升模型性能。

Imbalanced datasets pose a considerable challenge in training deep learning (DL) models for medical diagnostics, particularly for segmentation tasks. Imbalance may be associated with annotation quality limited annotated datasets, rare cases, or small-scale regions of interest (ROIs). These conditions adversely affect model training and performance, leading to segmentation boundaries which deviate from the true ROIs. Traditional loss functions, such as Binary Cross Entropy, replicate annotation biases and limit model generalization. We propose a novel, statistically driven, conditionally adaptive loss function (CALF) tailored to accommodate the conditions of imbalanced datasets in DL training. It employs a data-driven methodology by estimating imbalance severity using statistical methods of skewness and kurtosis, then applies an appropriate transformation to balance the training dataset while preserving data heterogeneity. This transformative approach integrates a multifaceted process, encompassing preprocessing, dataset filtering, and dynamic loss selection to achieve optimal outcomes. We benchmark our method against conventional loss functions using qualitative and quantitative evaluations. Experiments using large-scale open-source datasets (i.e., UPENN-GBM, UCSF, LGG, and BraTS) validate our approach, demonstrating substantial segmentation improvements. Code availability: https://anonymous.4open.science/r/MICCAI-Submission-43F9/.