构建医学知识图谱与多轮对话框架,让AI像医生一样逐步推理诊断。
The Multi-Round Diagnostic RAG Framework for Emulating Clinical Reasoning
- 构建覆盖中西医的876种疾病知识图谱,含7997节点和37201条三元组。
- 通过1908条标准化病历,缩小患者描述与专业术语间的语义差距。
- 多轮对话式RAG框架提升诊断准确率,结果获临床医生认可。
近年来,快速部署医疗大语言模型(LLMs)成为趋势,其中检索增强生成(RAG)因其快速部署和隐私保护优势受到关注。然而,制约RAG在医疗诊断中实际应用的关键挑战在于:患者口语化描述与医学知识库中专业术语之间的语义鸿沟。本文从数据和方法双角度出发解决该问题。首先,为弥补现有知识库的语义缺陷,构建了跨现代医学与中医的通用知识图谱DiagnosGraph,涵盖876种常见疾病,包含7,997个节点和37,201条三元组;同时引入1,908条经形式化处理的病历,将患者主诉转化为标准医学表述并标注诊断。其次,提出多轮诊断RAG(MRD-RAG)框架,通过多轮对话逐步细化诊断可能性,模拟医生的临床推理过程。在四个医疗基准上的实验,结合临床医生评估,验证了MRD-RAG显著提升了LLM的诊断性能,展现出实现更精准、更贴近人类思维的自动化诊断的巨大潜力。
原文摘要 · Abstract (English)
In recent years, accurately and quickly deploying medical large language models (LLMs) has become a trend. Among these, retrieval-augmented generation (RAG) has garnered attention due to rapid deployment and privacy protection. However, the challenge hinder the practical deployment of RAG for medical diagnosis: the semantic gap between colloquial patient descriptions and the professional terminology within medical knowledge bases. We try to address the challenge from the data perspective and the method perspective. First, to address the semantic gap in existing knowledge bases, we construct DiagnosGraph, a generalist knowledge graph covering both modern medicine and Traditional Chinese Medicine. It contains 876 common diseases with the graph of 7,997 nodes and 37,201 triples. To bridge the gap between colloquial patient narratives and academic medical knowledge, DiagnosGraph also introduces $1,908$ medical record by formalizing the patient chief complaint and proposing a medical diagnosis. Second, we introduce the Multi-Round Diagnostic RAG (MRD-RAG) framework. It utilizes a multi-round dialogue to refine diagnostic possibilities, emulating the clinical reasoning of a physician. Experiments conducted on four medical benchmarks, with evaluations by human physicians, demonstrate that MRD-RAG enhances the diagnostic performance of LLMs, highlighting its potential to make automated diagnosis more accurate and human-aligned.
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