arXiv:2504.09106cs.CV2025-04

用多尺度注意力融合眼底图像,提升糖尿病视网膜病变诊断准确率。

Multi-modal and Multi-view Fundus Image Fusion for Retinopathy Diagnosis via Multi-scale Cross-attention and Shifted Window Self-attention

  • 通过多尺度交叉注意力建模跨模态图像长程依赖关系。
  • 采用移位窗口自注意力捕捉多视角间相对位置,降低计算开销。
  • 在分类和报告生成任务中表现优异,适合临床辅助诊断使用。

联合解读多模态与多视角眼底图像对糖尿病视网膜病变预防至关重要,不同视角可呈现完整的三维眼球视野,不同模态可提供互补的病灶区域。相比单图,多模态与多视角眼底图像序列包含病灶特征的长程依赖关系。通过建模这些序列中的长程依赖,可更全面挖掘病灶区域,并识别模态特异性病灶。为学习长程依赖关系并融合不同模态间的多尺度病灶特征,本文设计基于多尺度交叉注意力的多模态眼底图像融合方法,解决了传统基于注意力的多模态医学融合方法中存在的静态感受野问题。为捕捉不同视角间的相对位置关系并融合跨视角的综合病灶特征,本文进一步设计基于移位窗口自注意力的多视角眼底图像融合方法,有效缓解了基于自注意力的多视角融合方法计算复杂度随图像尺寸和数量呈二次增长的问题。最后,构建多任务视网膜病变诊断框架,结合上述两种融合方法,帮助眼科医生减轻工作负担并提升诊断准确性。在视网膜病变分类与报告生成任务上的实验结果表明,该方法在临床实践中具有提升诊断效率与可靠性的潜力,分类准确率达到82.53%,报告生成的BLEU-1得分为0.543。

原文摘要 · Abstract (English)

The joint interpretation of multi-modal and multi-view fundus images is critical for retinopathy prevention, as different views can show the complete 3D eyeball field and different modalities can provide complementary lesion areas. Compared with single images, the sequence relationships in multi-modal and multi-view fundus images contain long-range dependencies in lesion features. By modeling the long-range dependencies in these sequences, lesion areas can be more comprehensively mined, and modality-specific lesions can be detected. To learn the long-range dependency relationship and fuse complementary multi-scale lesion features between different fundus modalities, we design a multi-modal fundus image fusion method based on multi-scale cross-attention, which solves the static receptive field problem in previous multi-modal medical fusion methods based on attention. To capture multi-view relative positional relationships between different views and fuse comprehensive lesion features between different views, we design a multi-view fundus image fusion method based on shifted window self-attention, which also solves the computational complexity of the multi-view fundus fusion method based on self-attention is quadratic to the size and number of multi-view fundus images. Finally, we design a multi-task retinopathy diagnosis framework to help ophthalmologists reduce workload and improve diagnostic accuracy by combining the proposed two fusion methods. The experimental results of retinopathy classification and report generation tasks indicate our method's potential to improve the efficiency and reliability of retinopathy diagnosis in clinical practice, achieving a classification accuracy of 82.53\% and a report generation BlEU-1 of 0.543.

眼底图像多模态融合注意力机制疾病诊断

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