仅用基础信息生成个人专属脑部核磁分割图,突破数据获取瓶颈。
Deep Generative Model-Based Generation of Synthetic Individual-Specific Brain MRI Segmentations
- 基于人口统计等易得信息,用深度生成模型合成个体化脑区分割图
- 生成的白质、灰质、脑脊液体积误差分别低至36.44、29.20、35.51mL
- 适合缺乏详细脑结构数据的研究者,推动个性化医疗建模
据我们所知,现有所有可为特定个体生成合成脑部磁共振成像(MRI)扫描的方法,均需个体脑部详细的结构或体积信息。但此类信息常难以获取、成本高昂。本文提出首个仅依赖易得的年龄、性别、访谈及认知测试等基本信息,即可生成个体化3D脑组织分割图(白质、灰质、脑脊液)的方法。我们设计了新型深度生成模型CSegSynth,其性能优于条件变分自编码器(C-VAE)、条件生成对抗网络(C-GAN)和条件潜空间扩散模型(C-LDM)。通过大量评估验证了生成分割图的高质量。在个体特异性生成有效性评估中,预测体积与真实体积的平均绝对误差分别为36.44mL(白质)、29.20mL(灰质)、35.51mL(脑脊液),表现优异。
原文摘要 · Abstract (English)
To the best of our knowledge, all existing methods that can generate synthetic brain magnetic resonance imaging (MRI) scans for a specific individual require detailed structural or volumetric information about the individual's brain. However, such brain information is often scarce, expensive, and difficult to obtain. In this paper, we propose the first approach capable of generating synthetic brain MRI segmentations -- specifically, 3D white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF) segmentations -- for individuals using their easily obtainable and often readily available demographic, interview, and cognitive test information. Our approach features a novel deep generative model, CSegSynth, which outperforms existing prominent generative models, including conditional variational autoencoder (C-VAE), conditional generative adversarial network (C-GAN), and conditional latent diffusion model (C-LDM). We demonstrate the high quality of our synthetic segmentations through extensive evaluations. Also, in assessing the effectiveness of the individual-specific generation, we achieve superior volume prediction, with mean absolute errors of only 36.44mL, 29.20mL, and 35.51mL between the ground-truth WM, GM, and CSF volumes of test individuals and those volumes predicted based on generated individual-specific segmentations, respectively.
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