arXiv:2504.13233cs.LG2025-04被引 3

用胎儿心电图生成多普勒超声信号,解决数据少难题。

Auto-FEDUS: Autoregressive Generative Modeling of Doppler Ultrasound Signals from Fetal Electrocardiograms

  • 基于扩张因果卷积的自回归模型,直接在波形上建模长短期依赖。
  • 生成信号形态接近真实数据,心率误差仅4.5次/分钟。
  • 适合缺乏多普勒超声数据的胎儿健康监测模型训练。

通过一维多普勒超声(DUS)信号进行胎儿健康监测具有成本低、易获取的优势,日益受到关注。然而,利用机器学习方法基于DUS信号评估母胎健康状况的研究仍有限,主要受限于缺乏大规模、有可靠参考标准的DUS数据集,以及不同孕周数据分布不均的问题。为此,我们提出一种新型自回归生成模型Auto-FEDUS,可将胎儿心电图(FECG)信号映射为对应的DUS波形。该模型采用基于扩张因果卷积的神经时间网络,直接在波形层面操作,有效捕捉信号中的短时与长时依赖关系,保持生成数据完整性。跨被试实验表明,Auto-FEDUS在时域与频域评估中均优于传统生成架构,生成的DUS信号形态与真实信号高度相似。质量评估模型判定所有生成信号均为优质,心率估计模型对生成与真实数据的结果相当,Bland-Altman一致性界限为4.5次/分钟。该方法为缓解数据稀缺问题、提升基于DUS的胎儿模型训练效果与泛化能力提供了新路径。

原文摘要 · Abstract (English)

Fetal health monitoring through one-dimensional Doppler ultrasound (DUS) signals offers a cost-effective and accessible approach that is increasingly gaining interest. Despite its potential, the development of machine learning based techniques to assess the health condition of mothers and fetuses using DUS signals remains limited. This scarcity is primarily due to the lack of extensive DUS datasets with a reliable reference for interpretation and data imbalance across different gestational ages. In response, we introduce a novel autoregressive generative model designed to map fetal electrocardiogram (FECG) signals to corresponding DUS waveforms (Auto-FEDUS). By leveraging a neural temporal network based on dilated causal convolutions that operate directly on the waveform level, the model effectively captures both short and long-range dependencies within the signals, preserving the integrity of generated data. Cross-subject experiments demonstrate that Auto-FEDUS outperforms conventional generative architectures across both time and frequency domain evaluations, producing DUS signals that closely resemble the morphology of their real counterparts. The realism of these synthesized signals was further gauged using a quality assessment model, which classified all as good quality, and a heart rate estimation model, which produced comparable results for generated and real data, with a Bland-Altman limit of 4.5 beats per minute. This advancement offers a promising solution for mitigating limited data availability and enhancing the training of DUS-based fetal models, making them more effective and generalizable.

生成模型胎儿监测多普勒超声自回归

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