用可穿戴设备区分双相与单相抑郁,精准度超96%。
Wearable-Derived Behavioral and Physiological Biomarkers for Classifying Unipolar and Bipolar Depression Severity
- 基于加速度计和体温等生理信号提取行为特征
- 加速度特征分类准确率达96.77%,体温特征达93.55%
- 为个性化抑郁症诊疗提供客观生物标志物支持
抑郁症是一种复杂的心理障碍,其表现远超传统主观评估范畴。近年来,研究越来越关注通过可穿戴设备实现无创、被动、连续的生理与行为监测,以更精准地捕捉抑郁的客观指标。然而,多数现有研究仅区分健康与抑郁状态,采用二元分类,难以体现抑郁异质性。本研究利用可穿戴设备预测抑郁症亚型——单相与双相抑郁,旨在识别具有区分性的生物标志物,提升诊断精度并支持个性化治疗。为此,我们构建了CALYPSO数据集,用于非侵入式检测抑郁亚型及症状,采集血容量脉搏、皮电活动、体表温度和三轴加速度信号。同时,我们使用经典特征与标准机器学习方法在该数据集上建立基准。初步结果显示,从加速度数据中提取的体力活动特征在区分单相与双相抑郁中表现最优,准确率达96.77%;基于体温的特征也展现出高区分能力,准确率达93.55%。这些发现表明,生理与行为监测在抑郁亚型分类中具有巨大潜力,有助于推动更精准的临床干预。
原文摘要 · Abstract (English)
Depression is a complex mental disorder characterized by a diverse range of observable and measurable indicators that go beyond traditional subjective assessments. Recent research has increasingly focused on objective, passive, and continuous monitoring using wearable devices to gain more precise insights into the physiological and behavioral aspects of depression. However, most existing studies primarily distinguish between healthy and depressed individuals, adopting a binary classification that fails to capture the heterogeneity of depressive disorders. In this study, we leverage wearable devices to predict depression subtypes-specifically unipolar and bipolar depression-aiming to identify distinctive biomarkers that could enhance diagnostic precision and support personalized treatment strategies. To this end, we introduce the CALYPSO dataset, designed for non-invasive detection of depression subtypes and symptomatology through physiological and behavioral signals, including blood volume pulse, electrodermal activity, body temperature, and three-axis acceleration. Additionally, we establish a benchmark on the dataset using well-known features and standard machine learning methods. Preliminary results indicate that features related to physical activity, extracted from accelerometer data, are the most effective in distinguishing between unipolar and bipolar depression, achieving an accuracy of $96.77\%$. Temperature-based features also showed high discriminative power, reaching an accuracy of $93.55\%$. These findings highlight the potential of physiological and behavioral monitoring for improving the classification of depressive subtypes, paving the way for more tailored clinical interventions.
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