提出可处理任意自然语言查询的视频时序定位框架，突破封闭集限制。

Temporal Action Detection and Moment Retrieval constitute two pivotal tasks in video understanding, focusing on precisely localizing temporal segments corresponding to specific actions or events. Recent advancements introduced Moment Detection to unify these two tasks, yet existing approaches remain confined to closed-set scenarios, limiting their applicability in open-world contexts. To bridge this gap, we present Grounding-MD, an innovative, grounded video-language pre-training framework tailored for open-world moment detection. Our framework incorporates an arbitrary number of open-ended natural language queries through a structured prompt mechanism, enabling flexible and scalable moment detection. Grounding-MD leverages a Cross-Modality Fusion Encoder and a Text-Guided Fusion Decoder to facilitate comprehensive video-text alignment and enable effective cross-task collaboration. Through large-scale pre-training on temporal action detection and moment retrieval datasets, Grounding-MD demonstrates exceptional semantic representation learning capabilities, effectively handling diverse and complex query conditions. Comprehensive evaluations across four benchmark datasets including ActivityNet, THUMOS14, ActivityNet-Captions, and Charades-STA demonstrate that Grounding-MD establishes new state-of-the-art performance in zero-shot and supervised settings in open-world moment detection scenarios. All source code and trained models will be released.