用网络模型模拟胰腺细胞分泌胰岛素和胰高血糖素的机制。
Glucagon and insulin production in pancreatic cells modeled using Petri nets and Boolean networks
- 用佩特里网建模胰岛β/α细胞分泌胰岛素与胰高血糖素的动态过程。
- 揭示血糖水平如何调控两种激素的协同分泌，实现血糖平衡。
- 将复杂模型转化为布尔网络，便于系统性分析与计算模拟。
糖尿病是一种以血液中葡萄糖持续升高为特征的慢性疾病。葡萄糖调节涉及众多复杂过程及其相互作用。为更好地理解这些过程，我们致力于构建全身葡萄糖调节的佩特里网模型。目前已完成肝糖酵解与葡萄糖合成的建模，以及健康与糖尿病患者葡萄糖调节的总体概览模型。本文提出胰岛β细胞胰岛素分泌及胰岛α细胞胰高血糖素分泌的佩特里网模型。这两种激素具有相反作用：胰岛素防止高血糖，胰高血糖素防止低血糖。理解其分泌机制是掌握糖尿病的基础。我们还构建了基于血糖水平动态调控的两者共存模型，并分析其动力学特性。此外，依据标准转换规则，将整个胰岛素与胰高血糖素分泌系统转化为布尔网络。
原文摘要 · Abstract (English)
Diabetes is a civilization chronic disease characterized by a constant elevated concentration of glucose in the blood. Many processes are involved in the glucose regulation, and their interactions are very complex. To better understand those processes we set ourselves a goal to create a Petri net model of the glucose regulation in the whole body. So far we have managed to create a model of glycolysis and synthesis of glucose in the liver, and the general overview models of the glucose regulation in a healthy and diabetic person. In this paper we introduce Petri nets models of insulin secretion in beta cell of the pancreas, and glucagon in the pancreas alpha cells. Those two hormones have mutually opposite effects: insulin preventing hyperglycemia, and glucagon preventing hypoglycemia. Understanding the mechanisms of insulin and glucagon secretion constitutes the basis for understanding diabetes. We also present a model in which both processes occur together, depending on the blood glucose level. The dynamics of each model is analysed. Additionally, we transform the overall insulin and glucagon secretion system to a Boolean network, following standard transformation rules.
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