针对脑电图信号设计自适应大模型，提升跨任务泛化能力

While foundation models excel in text, image, and video domains, the critical biological signals, particularly electroencephalography(EEG), remain underexplored. EEG benefits neurological research with its high temporal resolution, operational practicality, and safety profile. However, low signal-to-noise ratio, inter-subject variability, and cross-paradigm differences hinder the generalization of current models. Existing methods often employ simplified strategies, such as a single loss function or a channel-temporal joint representation module, and suffer from a domain gap between pretraining and evaluation tasks that compromises efficiency and adaptability. To address these limitations, we propose the Adaptive Large Foundation model for EEG signal representation(ALFEE) framework, a novel hybrid transformer architecture with two learning stages for robust EEG representation learning. ALFEE employs a hybrid attention that separates channel-wise feature aggregation from temporal dynamics modeling, enabling robust EEG representation with variable channel configurations. A channel encoder adaptively compresses variable channel information, a temporal encoder captures task-guided evolution, and a hybrid decoder reconstructs signals in both temporal and frequency domains. During pretraining, ALFEE optimizes task prediction, channel and temporal mask reconstruction, and temporal forecasting to enhance multi-scale and multi-channel representation. During fine-tuning, a full-model adaptation with a task-specific token dictionary and a cross-attention layer boosts performance across multiple tasks. After 25,000 hours of pretraining, extensive experimental results on six downstream EEG tasks demonstrate the superior performance of ALFEE over existing models. Our ALFEE framework establishes a scalable foundation for biological signal analysis with implementation at https://github.com/xw1216/ALFEE.