针对真实图像对的快速融合，实现一次拍摄即优化的高精度影像增强。

Deep learning has substantially advanced pansharpening, achieving impressive fusion quality. However, a prevalent limitation is that conventional deep learning models, which typically rely on training datasets, often exhibit suboptimal generalization to unseen real-world image pairs. This restricts their practical utility when faced with real-world scenarios not included in the training datasets. To overcome this, we introduce a two-stage random alternating framework (TRA-PAN) that performs instance-specific optimization for any given Multispectral(MS)/Panchromatic(PAN) pair, ensuring robust and high-quality fusion. TRA-PAN effectively integrates strong supervision constraints from reduced-resolution images with the physical characteristics of the full-resolution images. The first stage introduces a pre-training procedure, which includes Degradation-Aware Modeling (DAM) to capture spectral degradation mappings, alongside a warm-up procedure designed to reduce training time and mitigate the adverse effects of reduced-resolution data. The second stage employs Random Alternation Optimization (RAO), randomly alternating between reduced- and full-resolution images to refine the fusion model progressively. This adaptive, per-instance optimization strategy, operating in a one-shot manner for each MS/PAN pair, yields superior high-resolution multispectral images. Experimental results demonstrate that TRA-PAN outperforms state-of-the-art (SOTA) methods in quantitative metrics and visual quality in real-world scenarios, underscoring its enhanced practical applicability and robustness.