用AI筛选天然药物，为癫痫患者定制更有效的中药处方。
A Computational Approach to Epilepsy Treatment: An AI-optimized Global Natural Product Prescription System
- 结合机器学习与贝叶斯优化，从全球天然产物中智能匹配有效草药。
- 17种高疗效草药显著减少癫痫发作，临床试验显示效果提升28.5%。
- 适合对西药无效或副作用大的癫痫患者及中医现代化研究者。
癫痫是一种全球普遍的神经系统疾病，许多患者因传统抗癫痫药物疗效有限且副作用大而转向替代疗法。本研究开发了一种计算方法，通过人工智能驱动分析全球天然产物并结合统计验证的随机对照试验（RCT），优化中药治疗方案。系统整合机器学习算法用于草药-疗效特征刻画、贝叶斯优化实现个性化剂量调整，并基于48项涵盖48种癫痫病症（共5,216名患者）的随机对照试验进行循证推荐。利用LASSO回归与SHAP值分析，识别出17种高疗效草药（如天麻、印度人参），其在减少癫痫发作方面具有显著效果（p<0.01，Cohen's d=0.89），多重检验校正后仍具统计意义（p<0.001）。一项随机双盲验证试验（n=120）表明，使用AI优化的草药处方比常规方案平均减少28.5%的发作频率（95%置信区间：18.7%-37.3%，p=0.003）。
原文摘要 · Abstract (English)
Epilepsy is a prevalent neurological disease with millions of patients worldwide. Many patients have turned to alternative medicine due to the limited efficacy and side effects of conventional antiepileptic drugs. In this study, we developed a computational approach to optimize herbal epilepsy treatment through AI-driven analysis of global natural products and statistically validated randomized controlled trials (RCTs). Our intelligent prescription system combines machine learning (ML) algorithms for herb-efficacy characterization, Bayesian optimization for personalized dosing, and meta-analysis of RCTs for evidence-based recommendations. The system analyzed 1,872 natural compounds from traditional Chinese medicine (TCM), Ayurveda, and ethnopharmacological databases, integrating their bioactive properties with clinical outcomes from 48 RCTs covering 48 epilepsy conditions (n=5,216). Using LASSO regression and SHAP value analysis, we identified 17 high-efficacy herbs (e.g., Gastrodia elata [using é for accented characters], Withania somnifera), showing significant seizure reduction (p$<$0.01, Cohen's d=0.89) with statistical significance confirmed by multiple testing (p$<$0.001). A randomized double-blind validation trial (n=120) demonstrated 28.5\% greater seizure frequency reduction with AI-optimized herbal prescriptions compared to conventional protocols (95\% CI: 18.7-37.3\%, p=0.003).
Thank you to arXiv for use of its open access interoperability. PaperDance 不是 arXiv 官方产品；中文卡片由大模型生成，请以原文为准。