多对比激光内窥镜提升胃肠道成像对比度，助医生更早发现病变。
Multi-contrast laser endoscopy for in vivo gastrointestinal imaging
- 通过可调谐光谱、相干与方向照明，实现多模态成像。
- 在31个息肉中对比度提升约三倍，颜色差异提升五倍。
- 临床环境下无缝集成，适合内镜医生快速筛查病变。
白光内窥镜是胃肠道疾病检测的临床金标准，主要依赖组织颜色、纹理和形状的视觉异常。然而，这些特征的对比度常较微弱，导致许多临床相关病例被漏诊。为克服此挑战，我们提出多对比激光内窥镜（MLE）：一种具备快速可调光谱、相干与方向照明的宽视野临床成像平台。我们展示了三个功能：利用多光谱漫反射增强组织色团对比，通过激光散斑对比成像量化血流，以及使用光度立体术表征黏膜地形。在实验模型验证后，我们在临床结肠镜检查中实现了MLE的在体应用。对31个息肉的成像显示，相较于白光与窄带成像，对比度提升约三倍，颜色差异提升五倍。凭借可揭示多种互补组织对比的能力，并能无缝融入临床环境，MLE展现出作为胃肠成像辅助工具的巨大潜力。
原文摘要 · Abstract (English)
White light endoscopy is the clinical gold standard for detecting diseases in the gastrointestinal tract. Most applications involve identifying visual abnormalities in tissue color, texture, and shape. Unfortunately, the contrast of these features is often subtle, causing many clinically relevant cases to go undetected. To overcome this challenge, we introduce Multi-contrast Laser Endoscopy (MLE): a platform for widefield clinical imaging with rapidly tunable spectral, coherent, and directional illumination. We demonstrate three capabilities of MLE: enhancing tissue chromophore contrast with multispectral diffuse reflectance, quantifying blood flow using laser speckle contrast imaging, and characterizing mucosal topography using photometric stereo. We validate MLE with benchtop models, then demonstrate MLE in vivo during clinical colonoscopies. MLE images from 31 polyps demonstrate an approximate three-fold improvement in contrast and a five-fold improvement in color difference compared to white light and narrow band imaging. With the ability to reveal multiple complementary types of tissue contrast while seamlessly integrating into the clinical environment, MLE shows promise as an investigative tool to improve gastrointestinal imaging.
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