arXiv:2505.10993eess.IVcs.CV2025-05综述被引 8

综述病理学中生成模型的方法、应用与挑战,助力智能诊断发展。

Content Generation Models in Computational Pathology: A Comprehensive Survey on Methods, Applications, and Challenges

  • 按图像、文本、分子-形态等四类梳理生成技术演进
  • 分析150+研究,对比GAN、扩散模型等架构性能
  • 聚焦高保真切片生成难题与临床可解释性瓶颈

内容生成建模已成为计算病理学的新兴方向,具备数据高效学习、合成数据增强及面向任务的生成能力,适用于多种诊断场景。本综述系统梳理了该领域近年进展,涵盖四大核心方向:图像生成、文本生成、分子谱型-组织形态生成及其他专项生成应用。通过对150余篇代表性研究的分析,追踪了生成架构的演进历程——从早期生成对抗网络(GAN)到近期扩散模型与生成式视觉-语言模型的发展。文章还考察了常用数据集与评估协议,并指出现有局限,包括难以生成高保真全切片图像、临床可解释性不足,以及合成数据带来的伦理与法律风险。最后讨论开放性挑战与未来研究方向,强调构建集成化、可临床部署的生成系统的重要性。本文旨在为计算病理学中内容生成模型的研究者与实践者提供基础参考。

原文摘要 · Abstract (English)

Content generation modeling has emerged as a promising direction in computational pathology, offering capabilities such as data-efficient learning, synthetic data augmentation, and task-oriented generation across diverse diagnostic tasks. This review provides a comprehensive synthesis of recent progress in the field, organized into four key domains: image generation, text generation, molecular profile-morphology generation, and other specialized generation applications. By analyzing over 150 representative studies, we trace the evolution of content generation architectures -- from early generative adversarial networks to recent advances in diffusion models and generative vision-language models. We further examine the datasets and evaluation protocols commonly used in this domain and highlight ongoing limitations, including challenges in generating high-fidelity whole slide images, clinical interpretability, and concerns related to the ethical and legal implications of synthetic data. The review concludes with a discussion of open challenges and prospective research directions, with an emphasis on developing integrated and clinically deployable generation systems. This work aims to provide a foundational reference for researchers and practitioners developing content generation models in computational pathology.

生成模型计算病理合成数据医学AI

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