首个评估医学诊断推理过程的开源数据集,让大模型学得更像医生。
MedCaseReasoning: Evaluating and learning diagnostic reasoning from clinical case reports
- 构建1.4万例临床病例,匹配真实医生推理链条。
- 顶尖开源模型诊断准确率仅48%,推理回忆率64%。
- 用真实推理数据微调,诊断与推理能力平均提升41%以上。
医生和患者越来越多地使用大语言模型(LLMs)进行临床诊断。然而,与数学或编程等可客观判定结果的领域不同,医学诊断不仅要求最终答案正确,还需推理过程准确且忠实于临床思维。当前广泛使用的医疗基准(如MedQA和MMLU)仅评估最终答案的准确性,忽略了推理质量。为此,我们提出MedCaseReasoning,首个公开可用的数据集,用于评估LLMs在对齐临床医生诊断推理方面的能力。该数据集包含14,489个诊断问答案例,每例均配有来自公开医学病例报告的详细推理陈述。我们在MedCaseReasoning上评估了最先进的推理型LLMs,发现其诊断和推理存在显著不足:例如,表现最佳的开源模型DeepSeek-R1在10次提示下的诊断准确率为48%,仅能回忆起64%的医生推理内容(召回率)。然而,我们证明在从MedCaseReasoning中提取的推理轨迹上微调模型,可使诊断准确率和临床推理召回率平均相对提升29%和41%。相关数据集、代码和模型已开源,地址为https://github.com/kevinwu23/Stanford-MedCaseReasoning。
原文摘要 · Abstract (English)
Doctors and patients alike increasingly use Large Language Models (LLMs) to diagnose clinical cases. However, unlike domains such as math or coding, where correctness can be objectively defined by the final answer, medical diagnosis requires both the outcome and the reasoning process to be accurate. Currently, widely used medical benchmarks like MedQA and MMLU assess only accuracy in the final answer, overlooking the quality and faithfulness of the clinical reasoning process. To address this limitation, we introduce MedCaseReasoning, the first open-access dataset for evaluating LLMs on their ability to align with clinician-authored diagnostic reasoning. The dataset includes 14,489 diagnostic question-and-answer cases, each paired with detailed reasoning statements derived from open-access medical case reports. We evaluate state-of-the-art reasoning LLMs on MedCaseReasoning and find significant shortcomings in their diagnoses and reasoning: for instance, the top-performing open-source model, DeepSeek-R1, achieves only 48% 10-shot diagnostic accuracy and mentions only 64% of the clinician reasoning statements (recall). However, we demonstrate that fine-tuning LLMs on the reasoning traces derived from MedCaseReasoning significantly improves diagnostic accuracy and clinical reasoning recall by an average relative gain of 29% and 41%, respectively. The open-source dataset, code, and models are available at https://github.com/kevinwu23/Stanford-MedCaseReasoning.
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