用极少标注数据实现精准癌症图像分割,支持单点提示即刻生成结果。
Promptable cancer segmentation using minimal expert-curated data
- 结合弱监督与全监督分类器,通过单点提示引导搜索优化分割。
- 仅需24张全标注+8张弱标注图像,性能媲美全监督方法。
- 适合医疗标注资源稀缺但要求高精度的场景,如病理图像分析。
自动化癌症医学图像分割可辅助精准诊断与治疗,但受限于专家标注成本高及数据间观察者差异。虽弱监督方法减少标注需求,但仍需大量配对的组织学与图像数据,难以获取。提示可调分割虽可免于再训练,但在病灶区域表现不佳,仍需大规模数据训练。本文提出新方法,仅需24张全标注图像和8张弱标注图像即可训练。通过两个分类器(弱监督与全监督)协同,以单点提示启动引导式搜索,实现分割优化。该方法在前列腺癌分割任务中超越现有提示可调模型,性能接近全监督方法,且标注量减少达100倍,使高质量标注成为可能。
原文摘要 · Abstract (English)
Automated segmentation of cancer on medical images can aid targeted diagnostic and therapeutic procedures. However, its adoption is limited by the high cost of expert annotations required for training and inter-observer variability in datasets. While weakly-supervised methods mitigate some challenges, using binary histology labels for training as opposed to requiring full segmentation, they require large paired datasets of histology and images, which are difficult to curate. Similarly, promptable segmentation aims to allow segmentation with no re-training for new tasks at inference, however, existing models perform poorly on pathological regions, again necessitating large datasets for training. In this work we propose a novel approach for promptable segmentation requiring only 24 fully-segmented images, supplemented by 8 weakly-labelled images, for training. Curating this minimal data to a high standard is relatively feasible and thus issues with the cost and variability of obtaining labels can be mitigated. By leveraging two classifiers, one weakly-supervised and one fully-supervised, our method refines segmentation through a guided search process initiated by a single-point prompt. Our approach outperforms existing promptable segmentation methods, and performs comparably with fully-supervised methods, for the task of prostate cancer segmentation, while using substantially less annotated data (up to 100X less). This enables promptable segmentation with very minimal labelled data, such that the labels can be curated to a very high standard.
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