0.55T磁共振可实现高质量脑功能成像，适合临床和研究使用。
A Feasibility Study of Task-Based fMRI at 0.55 T
- 采用自定义分析方法与EPI序列结合，实现全脑覆盖任务态fMRI
- 5至10分钟任务下检测到显著脑区激活，定位与强度接近高场效果
- 为低场磁共振在神经科学中的应用提供可行性支持
相比传统场强，0.55T MRI具有减少伪影、兼容同步脑电记录等优势，但此前尚未充分证明其在任务态fMRI中的可靠性。本研究建立了一套在0.55T下可行的任务态fMRI采集与分析流程，实现全脑覆盖，激活范围与位置与预期水平相当。通过结合EPI序列与定制分析技术，使用手指敲击和视觉任务，对比5分钟与10分钟扫描时长以提升激活检测能力。结果表明，在单个受试者中即可获得显著激活，证明0.55T上可靠的任务态fMRI是可行的。该研究为高场磁共振不可用或不适用场景下的功能神经成像提供了新可能，有助于推动临床诊断与科研应用的普及。
原文摘要 · Abstract (English)
0.55T MRI offers advantages compared to conventional field strengths, including reduced susceptibility artifacts and better compatibility with simultaneous EEG recordings. However, reliable task-based fMRI at 0.55T has not been significantly demonstrated. In this study, we establish a robust task-based fMRI protocol and analysis pipeline at 0.55T that achieves full brain coverage and results comparable to what is expected for activation extent and location. We attempted fMRI at 0.55T by combining EPI acquisition with custom analysis techniques. Finger-tapping and visual tasks were used, comparing 5- and 10-minute runs to enhance activation detection. The results show significant activations, demonstrating that high-quality task-based fMRI is achievable at 0.55T in single subjects. This study demonstrates that reliable task-based fMRI is feasible on 0.55T scanners, potentially broadening functional neuroimaging access in clinical and research settings where high-field MRI is unavailable or impractical, supporting broader diagnostic and research applications.
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