用深度强化学习自动调整心脏磁共振切面,省时又准确。
Adaptive Plane Reformatting for 4D Flow MRI using Deep Reinforcement Learning
- 基于局部坐标系的强化学习框架,不依赖固定解剖标志。
- 平均角度误差6.32度,距离误差3.40毫米,优于传统方法。
- 跨设备兼容性强,适合临床快速评估血流动力学。
四维相位对比磁共振成像(4D flow MRI)的平面重格式化耗时且易受观察者差异影响,限制了心血管血流的快速评估。本文提出AdaPR(自适应平面重格式化)框架,采用深度强化学习(DRL)结合异步优势演员-评论家(A3C)算法,利用局部坐标系实现对任意位置和方向图像的精准平面调整,无需依赖详细解剖标志。在88个来自多厂商的4D flow MRI数据集上验证,包括先天性心脏病患者。AdaPR平均角度误差为6.32 ± 4.15度,距离误差为3.40 ± 2.75毫米,优于基于全局坐标的DRL方法及非DRL方法。在不同体位下保持一致精度,其血流测量结果与两位人工观察者无显著差异,相关系数分别为R² = 0.972和R² = 0.968,接近观察者间一致性(R² = 0.969)。结果表明,AdaPR可实现鲁棒、方向无关的4D flow MRI平面重格式化,血流定量媲美专家水平,具备跨设备、跨机构的泛化能力,适用于更广泛的医学影像应用。
原文摘要 · Abstract (English)
Background and Objective: Plane reformatting for four-dimensional phase contrast MRI (4D flow MRI) is time-consuming and prone to inter-observer variability, which limits fast cardiovascular flow assessment. Deep reinforcement learning (DRL) trains agents to iteratively adjust plane position and orientation, enabling accurate plane reformatting without the need for detailed landmarks, making it suitable for images with limited contrast and resolution such as 4D flow MRI. However, current DRL methods assume that test volumes share the same spatial alignment as the training data, limiting generalization across scanners and institutions. To address this limitation, we introduce AdaPR (Adaptive Plane Reformatting), a DRL framework that uses a local coordinate system to navigate volumes with arbitrary positions and orientations. Methods: We implemented AdaPR using the Asynchronous Advantage Actor-Critic (A3C) algorithm and validated it on 88 4D flow MRI datasets acquired from multiple vendors, including patients with congenital heart disease. Results: AdaPR achieved a mean angular error of 6.32 +/- 4.15 degrees and a distance error of 3.40 +/- 2.75 mm, outperforming global-coordinate DRL methods and alternative non-DRL methods. AdaPR maintained consistent accuracy under different volume orientations and positions. Flow measurements from AdaPR planes showed no significant differences compared to two manual observers, with excellent correlation (R^2 = 0.972 and R^2 = 0.968), comparable to inter-observer agreement (R^2 = 0.969). Conclusion: AdaPR provides robust, orientation-independent plane reformatting for 4D flow MRI, achieving flow quantification comparable to expert observers. Its adaptability across datasets and scanners makes it a promising candidate for medical imaging applications beyond 4D flow MRI.
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