用神经微分方程生成和配准主动脉解剖结构,高效且精准。
Deformable registration and generative modelling of aortic anatomies by auto-decoders and neural ODEs
- 通过神经ODE建模空间变形,用低维编码自适应控制形状变化。
- 在健康主动脉数据上实现高精度配准,计算成本低。
- 支持生成新解剖形态,适合医学图像生成与个性化建模。
本文提出AD-SVFD,一种用于血管形状可变形配准及合成解剖结构生成的深度学习模型。该模型将每个几何体表示为加权点云,将环境空间变形建模为神经ODE在单位时间的解,其右端项由人工神经网络表达。通过最小化变形后点云与参考点云间的Chamfer Distance优化模型参数,反向积分ODE定义逆变换。其独特之处在于自解码器结构,支持跨解剖群体泛化并促进权重共享:每个解剖结构对应一个低维编码,作为自条件场与网络参数联合优化。推理时仅需微调潜变量编码,显著降低计算开销。此外,隐式形状表示支持生成应用:通过潜空间采样并施加相应逆变换至参考几何,即可生成新解剖结构。数值实验基于健康主动脉解剖数据,验证了该方法在保持竞争力计算成本下实现高质量结果。
原文摘要 · Abstract (English)
This work introduces AD-SVFD, a deep learning model for the deformable registration of vascular shapes to a pre-defined reference and for the generation of synthetic anatomies. AD-SVFD operates by representing each geometry as a weighted point cloud and models ambient space deformations as solutions at unit time of ODEs, whose time-independent right-hand sides are expressed through artificial neural networks. The model parameters are optimized by minimizing the Chamfer Distance between the deformed and reference point clouds, while backward integration of the ODE defines the inverse transformation. A distinctive feature of AD-SVFD is its auto-decoder structure, that enables generalization across shape cohorts and favors efficient weight sharing. In particular, each anatomy is associated with a low-dimensional code that acts as a self-conditioning field and that is jointly optimized with the network parameters during training. At inference, only the latent codes are fine-tuned, substantially reducing computational overheads. Furthermore, the use of implicit shape representations enables generative applications: new anatomies can be synthesized by suitably sampling from the latent space and applying the corresponding inverse transformations to the reference geometry. Numerical experiments, conducted on healthy aortic anatomies, showcase the high-quality results of AD-SVFD, which yields extremely accurate approximations at competitive computational costs.
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