纳米颗粒+植物提取物制成外用凝胶，显著缓解银屑病炎症和促进愈合。
Advanced Nanostructured Topical Therapeutics for Psoriasis: Strategic Synthesis, Multimodal Characterization, and Preliminary Pharmacodynamic Profiling
- 将氧化铈、氧化锌、银纳米颗粒与植物抗氧化剂复合于鱼胶-琼脂凝胶中。
- 动物实验显示第3天起炎症减轻，第14天疗效显著（p<0.001）。
- 适合关注天然成分与纳米药物协同治疗的皮肤科研究者参考。
银屑病是一种长期炎症性皮肤病，治疗困难。本研究通过将氧化铈（CeO2）、氧化锌（ZnO）和银（Ag）纳米颗粒与天然植物提取物结合，制备了基于鱼胶和琼脂的外用凝胶。利用紫外-可见光谱、动态光散射（DLS）、傅里叶变换红外光谱（FTIR）和扫描电子显微镜（SEM）对纳米颗粒进行表征，结果显示其具有良好的稳定性及均匀粒径分布（ZnO平均66 nm）。为增强治疗潜力，凝胶中添加了苦瓜、姜黄和印楝来源的植物抗氧化剂。在银屑病动物模型中测试该制剂，治疗组较安慰剂组和未处理组表现出更快的伤口愈合速度和更显著的抗炎效果，自第3天起即达统计学显著差异（p < 0.01 至 p < 0.001），并在第14天更加明显。结果表明，纳米颗粒与植物成分复合的外用凝胶可能为银屑病治疗提供新策略。建议进一步开展长期安全性和疗效评估。
原文摘要 · Abstract (English)
Psoriasis is a long-term inflammatory skin disease that remains difficult to treat. In this study, we developed a new topical treatment by combining metal oxide nanoparticles: cerium oxide (CeO2), zinc oxide (ZnO), and silver (Ag), with natural plant extracts in a gel made from fish collagen and agar. The nanoparticles were characterized using UV-Vis spectroscopy, dynamic light scattering (DLS), Fourier-transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM), showing good stability and a uniform particle size distribution (ZnO averaged 66 nm). To enhance therapeutic potential, the gel was enriched with plant-derived antioxidants from bitter melon, ginger, and neem. This formulation was tested on an animal model of psoriasis. The treated group exhibited faster wound healing and reduced inflammation compared to both placebo and untreated groups, with statistically significant results (p < 0.01 to p < 0.001) observed from Day 3, becoming more pronounced by Day 14. These results indicate that the combination of nanoparticles with plant-based components in a topical gel may provide a promising new approach to psoriasis treatment. Further studies are recommended to evaluate long-term safety and therapeutic effectiveness.
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