arXiv:2506.03185eess.IVcs.AI2025-06

首个基于病理图像的供肝评估基准,助力术中快速精准判断肝源质量。

DLiPath: A Benchmark for the Comprehensive Assessment of Donor Liver Based on Histopathological Image Dataset

  • 构建首个供肝病理图像基准DLiPath,含636张全片扫描图
  • 9种先进多实例学习模型在关键指标上表现优异,准确率显著提升
  • 适合医学图像分析与移植评估研究者使用,推动智能诊断发展

病理科医生对供体肝脏活检的全面评估对于决定是否接受或放弃潜在移植物至关重要。然而,在术中快速且准确地完成此类评估对病理学家而言仍具挑战性。供肝活检中的门脉纤维化、脂肪变性、大泡性脂肪变和肝细胞气球样变等特征与移植预后相关,但量化这些指标存在显著的观察者间和观察者内差异。为此,我们提出DLiPath,首个基于组织病理图像数据集的供肝全面评估基准。我们从中南大学湘雅三院病理科收集并公开发布了来自304名供体患者的636张全片扫描图像,并由专家标注了胆汁淤积、门脉纤维化、门脉炎、总脂肪变性、大泡性脂肪变性和肝细胞气球样变等关键病理特征。基于该数据集,我们选取九种先进的多实例学习(MIL)模型作为基线,进行了广泛的对比分析。实验结果表明,多个MIL模型在DLiPath上的各项评估指标上均达到高准确率,为未来自动化、智能化的供肝评估研究指明了方向。数据与代码已公开于https://github.com/panliangrui/ACM_MM_2025。

原文摘要 · Abstract (English)

Pathologists comprehensive evaluation of donor liver biopsies provides crucial information for accepting or discarding potential grafts. However, rapidly and accurately obtaining these assessments intraoperatively poses a significant challenge for pathologists. Features in donor liver biopsies, such as portal tract fibrosis, total steatosis, macrovesicular steatosis, and hepatocellular ballooning are correlated with transplant outcomes, yet quantifying these indicators suffers from substantial inter- and intra-observer variability. To address this, we introduce DLiPath, the first benchmark for comprehensive donor liver assessment based on a histopathology image dataset. We collected and publicly released 636 whole slide images from 304 donor liver patients at the Department of Pathology, the Third Xiangya Hospital, with expert annotations for key pathological features (including cholestasis, portal tract fibrosis, portal inflammation, total steatosis, macrovesicular steatosis, and hepatocellular ballooning). We selected nine state-of-the-art multiple-instance learning (MIL) models based on the DLiPath dataset as baselines for extensive comparative analysis. The experimental results demonstrate that several MIL models achieve high accuracy across donor liver assessment indicators on DLiPath, charting a clear course for future automated and intelligent donor liver assessment research. Data and code are available at https://github.com/panliangrui/ACM_MM_2025.

病理图像供肝评估多实例学习医学影像

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